Novel therapeutic strategies for degenerative disc disease: Review of cell
biology and intervertebral disc cell therapy
#MMPMID29568524
Fernandez-Moure J
; Moore CA
; Kim K
; Karim A
; Smith K
; Barbosa Z
; Van Eps J
; Rameshwar P
; Weiner B
SAGE Open Med
2018[]; 6
(?): 2050312118761674
PMID29568524
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Intervertebral disc degeneration is a disease of the discs connecting adjoining
vertebrae in which structural damage leads to loss of disc integrity.
Degeneration of the disc can be a normal process of ageing, but can also be
precipitated by other factors. Literature has made substantial progress in
understanding the biological basis of intervertebral disc, which is reviewed
here. Current medical and surgical management strategies have shortcomings that
do not lend promise to be effective solutions in the coming years. With advances
in understanding the cell biology and characteristics of the intervertebral disc
at the molecular and cellular level that have been made, alternative strategies
for addressing disc pathology can be discovered. A brief overview of the
anatomic, cellular, and molecular structure of the intervertebral disc is
provided as well as cellular and molecular pathophysiology surrounding
intervertebral disc degeneration. Potential therapeutic strategies involving stem
cell, protein, and genetic therapy for intervertebral disc degeneration are
further discussed.
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