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10.2147/OTT.S153798 http://scihub22266oqcxt.onion/10.2147/OTT.S153798 C5857153!5857153 !29559796     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29559796 &cmd=llinks): Failed to open stream: HTTP request failed! 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Rhein inhibits malignant phenotypes of human renal cell carcinoma by impacting on MAPK/NF-?B signaling pathways |pdf=|usr=}}{{29559796 }} gab.com Text Rhein inhibits malignant phenotypes of human renal cell carcinoma by impacting on MAPK/NF- B signaling pathways JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29559796 #FOAvip BACKGROUND: Rhein, an anthraquinone derivative of rhubarb, is traditionally used in Chinese herbal medicine. Now emerging studies suggest its antitumor properties in many human cancers. The present study aims to investigate the antitumor role of Rhein and its possible mechanism in human renal cell carcinoma (RCC). MATERIALS AND METHODS: Three RCC cell lines (A489, 786-O and ACHN) were used as the cell models. We applied CCK-8, cell counting, colony formation, wound healing and Transwell assays to assess the antitumor roles of Rhein in RCC cells in vitro. The therapeutic efficacy of Rhein was further evaluated by intraperitoneal administrations in tumor formation of mice. Western blot was used to investigate the underlying mechanisms of action of Rhein. RESULTS: Rhein inhibited RCC cell proliferation in a dose- and time-dependent manner. It also suppressed RCC cell migration and invasion in vitro. Moreover, Rhein was able to inhibit tumor growth in nude mice by intraperitoneal administration in vivo. Mechanistically, the protein levels of phosphorylated MAPK (mitogen-activated protein kinase, extracellular signal-regulated kinase and c-Jun N-terminal kinase), phosphorylated Akt and two targets of NF-?B (nuclear factor kappa-light-chain enhancer of activated B cells) pathway, matrix metalloproteinase 9 and CCND1 were all markedly reduced by Rhein treatment. CONCLUSION: Rhein processed the antitumor effects in RCC cells by inhibiting cell proliferation, migration and invasion, and these tumor-suppressing functions might be mediated by MAPK/NF-?B signaling pathways. Twit Text FOAVip Rhein inhibits malignant phenotypes of human renal cell carcinoma by impacting on MAPK/NF- B signaling pathways ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29559796 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29559796 #FOAvip English Wikipedia <ref>{{Cite pmid|29559796 }}</ref> Rhein inhibits malignant phenotypes of human renal cell carcinoma by impacting on MAPK/NF-?B signaling pathways #MMPMID29559796 Ma YL ; Chen F ; Shi J Onco Targets Ther 2018[]; 11 (ä): 1385-1394 PMID29559796 show ga BACKGROUND: Rhein, an anthraquinone derivative of rhubarb, is traditionally used in Chinese herbal medicine. Now emerging studies suggest its antitumor properties in many human cancers. The present study aims to investigate the antitumor role of Rhein and its possible mechanism in human renal cell carcinoma (RCC). MATERIALS AND METHODS: Three RCC cell lines (A489, 786-O and ACHN) were used as the cell models. We applied CCK-8, cell counting, colony formation, wound healing and Transwell assays to assess the antitumor roles of Rhein in RCC cells in vitro. The therapeutic efficacy of Rhein was further evaluated by intraperitoneal administrations in tumor formation of mice. Western blot was used to investigate the underlying mechanisms of action of Rhein. RESULTS: Rhein inhibited RCC cell proliferation in a dose- and time-dependent manner. It also suppressed RCC cell migration and invasion in vitro. Moreover, Rhein was able to inhibit tumor growth in nude mice by intraperitoneal administration in vivo. Mechanistically, the protein levels of phosphorylated MAPK (mitogen-activated protein kinase, extracellular signal-regulated kinase and c-Jun N-terminal kinase), phosphorylated Akt and two targets of NF-?B (nuclear factor kappa-light-chain enhancer of activated B cells) pathway, matrix metalloproteinase 9 and CCND1 were all markedly reduced by Rhein treatment. CONCLUSION: Rhein processed the antitumor effects in RCC cells by inhibiting cell proliferation, migration and invasion, and these tumor-suppressing functions might be mediated by MAPK/NF-?B signaling pathways. äRhein inhibits malignant phenotypes of human renal cell carcinoma by i(epmc).pdf DeepDyve Pubget Overpricing