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10.1038/s41467-018-03486-4 http://scihub22266oqcxt.onion/10.1038/s41467-018-03486-4 C5856775!5856775!29549242     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29549242|t=2018. SUMO targets the APC/C to regulate transition from metaphase to anaphase |pdf=|usr=}}{{29549242}} gab.com Text SUMO targets the APC/C to regulate transition from metaphase to anaphase JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29549242 #FOAvip Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects in mitotic chromosome separation. Searching for relevant SUMOylated proteins in mitosis, we identify the anaphase-promoting complex/cyclosome (APC/C), a master regulator of metaphase to anaphase transition. The APC4 subunit is the major SUMO target in the complex, containing SUMO acceptor lysines at positions 772 and 798. SUMOylation is crucial for accurate progression of cells through mitosis and increases APC/C ubiquitylation activity toward a subset of its targets, including the newly identified target KIF18B. Combined, our findings demonstrate the importance of SUMO signal transduction for genome integrity during mitotic progression and reveal how SUMO and ubiquitin cooperate to drive mitosis. Twit Text FOAVip SUMO targets the APC/C to regulate transition from metaphase to anaphase ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29549242 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29549242 #FOAvip English Wikipedia <ref>{{Cite pmid|29549242}}</ref> SUMO targets the APC/C to regulate transition from metaphase to anaphase #MMPMID29549242 Eifler K; Cuijpers SAG; Willemstein E; Raaijmakers JA; El Atmioui D; Ovaa H; Medema RH; Vertegaal ACO Nat Commun 2018[]; 9 (ä): ä PMID29549242show ga Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects in mitotic chromosome separation. Searching for relevant SUMOylated proteins in mitosis, we identify the anaphase-promoting complex/cyclosome (APC/C), a master regulator of metaphase to anaphase transition. The APC4 subunit is the major SUMO target in the complex, containing SUMO acceptor lysines at positions 772 and 798. SUMOylation is crucial for accurate progression of cells through mitosis and increases APC/C ubiquitylation activity toward a subset of its targets, including the newly identified target KIF18B. Combined, our findings demonstrate the importance of SUMO signal transduction for genome integrity during mitotic progression and reveal how SUMO and ubiquitin cooperate to drive mitosis. äSUMO targets the APC/C to regulate transition from metaphase to anapha(epmc).pdf DeepDyve Pubget Overpricing