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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pediatr+Infect+Dis+J 2010 ; 29 (7): 585-90 Nephropedia Template TP
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Influenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003?2008 #MMPMID20589966
Dawood FS; Fiore A; Kamimoto L; Nowell M; Reingold A; Gershman K; Meek J; Hadler J; Arnold KE; Ryan P; Lynfield R; Morin C; Baumbach J; Zansky S; Bennett NM; Thomas A; Schaffner W; Kirschke D; Finelli L
Pediatr Infect Dis J 2010[Jul]; 29 (7): 585-90 PMID20589966show ga
Background: Pneumonia is one of the most common complications in children hospitalized with influenza. We describe hospitalized children with influenza-associated pneumonia and associated risk indicators. Methods: Through Emerging Infections Program Network population-based surveillance, children aged <18 years hospitalized with laboratory-confirmed influenza with a chest radiograph during hospitalization were identified during the 2003?2008 influenza seasons. A case with radiologically confirmed influenza-associated pneumonia was defined as a child from the surveillance area hospitalized with: (1) laboratory-confirmed influenza and (2) evidence of new pneumonia on chest radiograph during hospitalization. Hospitalized children with pneumonia were compared with those without pneumonia by univariate and multivariate analysis. Results: Overall, 2992 hospitalized children with influenza with a chest radiograph were identified; 1072 (36%) had influenza-associated pneumonia. When compared with children hospitalized with influenza without pneumonia, hospitalized children with influenza-associated pneumonia were more likely to require intensive care unit admission (21% vs. 11%, P < 0.01), develop respiratory failure (11% versus 3%, P < 0.01), and die (0.9% vs. 0.3% P = 0.01). In multivariate analysis, age 6 to 23 months (adjusted OR: 2.1, CI: 1.6 ?2.8), age 2 to 4 years (adjusted OR: 1.7, CI: 1.3?2.2), and asthma (adjusted OR: 1.4, CI: 1.1?1.8) were significantly associated with influenza-associated pneumonia. Conclusions: Hospitalized children with influenza-associated pneumonia were more likely to have a severe clinical course than other hospitalized children with influenza, and children aged 6 months to 4 years and those with asthma were more likely to have influenza-associated pneumonia. Identifying children at greater risk for influenza-associated pneumonia will inform prevention and treatment strategies targeting children at risk for influenza complications.