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2010 ; 29
(7
): 585-90
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Influenza-associated pneumonia in children hospitalized with laboratory-confirmed
influenza, 2003-2008
#MMPMID20589966
Dawood FS
; Fiore A
; Kamimoto L
; Nowell M
; Reingold A
; Gershman K
; Meek J
; Hadler J
; Arnold KE
; Ryan P
; Lynfield R
; Morin C
; Baumbach J
; Zansky S
; Bennett NM
; Thomas A
; Schaffner W
; Kirschke D
; Finelli L
Pediatr Infect Dis J
2010[Jul]; 29
(7
): 585-90
PMID20589966
show ga
BACKGROUND: Pneumonia is one of the most common complications in children
hospitalized with influenza. We describe hospitalized children with
influenza-associated pneumonia and associated risk indicators. METHODS: Through
Emerging Infections Program Network population based surveillance, children aged
<18 years hospitalized with laboratory confirmed influenza with a chest
radiograph during hospitalization were identified during the 2003-2008 influenza
seasons. A case with radiologically confirmed influenza-associated pneumonia was
defined as a child from the surveillance area hospitalized with: (1)
laboratory-confirmed influenza and (2) evidence of new pneumonia on chest
radiograph during hospitalization. Hospitalized children with pneumonia were
compared with those without pneumonia by univariate and multivariate analysis.
RESULTS: Overall, 2992 hospitalized children with influenza with a chest
radiograph were identified; 1072 (36%) had influenza-associated pneumonia.When
compared with children hospitalized with influenza without pneumonia,
hospitalized children with influenza-associated pneumonia were more likely to
require intensive care unit admission (21% vs. 11%, P < 0.01), develop
respiratory failure (11% versus 3%, P < 0.01), and die(0.9% vs. 0.3% P 0.01). In
multivariate analysis, age 6 to 23 months(adjusted OR: 2.1, CI: 1.6 -2.8), age 2
to 4 years (adjusted OR: 1.7, CI:1.3-2.2), and asthma (adjusted OR: 1.4, CI:
1.1-1.8) were significantly associated with influenza-associated pneumonia.
CONCLUSIONS: Hospitalized children with influenza-associated pneumonia were more
likely to have a severe clinical course than other hospitalized children with
influenza, and children aged 6 months to 4 years and those with asthma were more
likely to have influenza-associated pneumonia.Identifying children at greater
risk for influenza-associated pneumonia will inform prevention and treatment
strategies targeting children at risk for influenza complications.
|*Hospitalization
[MESH]
|Adolescent
[MESH]
|Age Factors
[MESH]
|Asthma/complications
[MESH]
|Child
[MESH]
|Child, Preschool
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Infant
[MESH]
|Infant, Newborn
[MESH]
|Influenza A virus/*isolation & purification
[MESH]