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10.1097/inf.0b013e3181d411c5

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suck abstract from ncbi


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pmid20589966
      Pediatr+Infect+Dis+J 2010 ; 29 (7 ): 585-90
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  • Influenza-associated pneumonia in children hospitalized with laboratory-confirmed influenza, 2003-2008 #MMPMID20589966
  • Dawood FS ; Fiore A ; Kamimoto L ; Nowell M ; Reingold A ; Gershman K ; Meek J ; Hadler J ; Arnold KE ; Ryan P ; Lynfield R ; Morin C ; Baumbach J ; Zansky S ; Bennett NM ; Thomas A ; Schaffner W ; Kirschke D ; Finelli L
  • Pediatr Infect Dis J 2010[Jul]; 29 (7 ): 585-90 PMID20589966 show ga
  • BACKGROUND: Pneumonia is one of the most common complications in children hospitalized with influenza. We describe hospitalized children with influenza-associated pneumonia and associated risk indicators. METHODS: Through Emerging Infections Program Network population based surveillance, children aged <18 years hospitalized with laboratory confirmed influenza with a chest radiograph during hospitalization were identified during the 2003-2008 influenza seasons. A case with radiologically confirmed influenza-associated pneumonia was defined as a child from the surveillance area hospitalized with: (1) laboratory-confirmed influenza and (2) evidence of new pneumonia on chest radiograph during hospitalization. Hospitalized children with pneumonia were compared with those without pneumonia by univariate and multivariate analysis. RESULTS: Overall, 2992 hospitalized children with influenza with a chest radiograph were identified; 1072 (36%) had influenza-associated pneumonia.When compared with children hospitalized with influenza without pneumonia, hospitalized children with influenza-associated pneumonia were more likely to require intensive care unit admission (21% vs. 11%, P < 0.01), develop respiratory failure (11% versus 3%, P < 0.01), and die(0.9% vs. 0.3% P 0.01). In multivariate analysis, age 6 to 23 months(adjusted OR: 2.1, CI: 1.6 -2.8), age 2 to 4 years (adjusted OR: 1.7, CI:1.3-2.2), and asthma (adjusted OR: 1.4, CI: 1.1-1.8) were significantly associated with influenza-associated pneumonia. CONCLUSIONS: Hospitalized children with influenza-associated pneumonia were more likely to have a severe clinical course than other hospitalized children with influenza, and children aged 6 months to 4 years and those with asthma were more likely to have influenza-associated pneumonia.Identifying children at greater risk for influenza-associated pneumonia will inform prevention and treatment strategies targeting children at risk for influenza complications.
  • |*Hospitalization [MESH]
  • |Adolescent [MESH]
  • |Age Factors [MESH]
  • |Asthma/complications [MESH]
  • |Child [MESH]
  • |Child, Preschool [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Infant [MESH]
  • |Infant, Newborn [MESH]
  • |Influenza A virus/*isolation & purification [MESH]
  • |Influenza, Human/*complications [MESH]
  • |Male [MESH]
  • |Pneumonia, Bacterial/complications/*epidemiology/mortality/pathology [MESH]
  • |Radiography, Thoracic [MESH]
  • |Respiratory Insufficiency/epidemiology [MESH]


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