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10.3390/s18020426

http://scihub22266oqcxt.onion/10.3390/s18020426
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C5855898!5855898!29389878
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suck abstract from ncbi


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pmid29389878      Sensors+(Basel) 2018 ; 18 (2): ä
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  • Amyloid Beta Detection by Faradaic Electrochemical Impedance Spectroscopy Using Interdigitated Microelectrodes #MMPMID29389878
  • Park JS; Kim HJ; Lee JH; Park JH; Kim J; Hwang KS; Lee BC
  • Sensors (Basel) 2018[Feb]; 18 (2): ä PMID29389878show ga
  • Faradaic electrochemical impedance spectroscopy (f-EIS) in the presence of redox reagent, e.g., [Fe(CN)6]3?/4?, is widely used in biosensors owing to its high sensitivity. However, in sensors detecting amyloid beta (A?), the redox reagent can cause the aggregation of A?, which is a disturbance factor in accurate detection. Here, we propose an interdigitated microelectrode (IME) based f-EIS technique that can alleviate the aggregation of A? and achieve high sensitivity by buffer control. The proposed method was verified by analyzing three different EIS-based sensors: non-faradaic EIS (nf-EIS), f-EIS, and the proposed f-EIS with buffer control. We analyzed the equivalent circuits of nf-EIS and f-EIS sensors. The dominant factors of sensitivity were analyzed, and the impedance change rates via A? reaction was compared. We measured the sensitivity of the IME sensors based on nf-EIS, f-EIS, and the proposed f-EIS. The results demonstrate that the proposed EIS-based IME sensor can detect A? with a sensitivity of 7.40-fold and 10.93-fold higher than the nf-EIS and the f-EIS sensors, respectively.
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