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10.3390/ijms19020476 http://scihub22266oqcxt.onion/10.3390/ijms19020476 C5855698!5855698!29415457     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (2): ä Nephropedia Template TP {{tp|p=29415457|t=2018. Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity |pdf=|usr=}}{{29415457}} gab.com Text Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29415457 #FOAvip Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the underlying molecular mechanisms remained unclear. The breakthrough discovery that the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes. Our group and others showed that altered ZnT8 function may be involved in the pathogenesis of type 2 diabetes, indicating that the precise control of zinc homeostasis is crucial for maintaining health and preventing various diseases, including lifestyle-associated diseases. Recently, the role of the zinc transporter ZIP13 in the regulation of beige adipocyte biogenesis was clarified, which indicated zinc homeostasis regulation as a possible therapeutic target for obesity and metabolic syndrome. Here we review advances in the role of zinc homeostasis in the pathophysiology of diabetes, and propose that inadequate zinc distribution may affect the onset of diabetes and metabolic diseases by regulating various critical biological events. Twit Text FOAVip Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29415457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29415457 #FOAvip English Wikipedia <ref>{{Cite pmid|29415457}}</ref> Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity #MMPMID29415457 Fukunaka A; Fujitani Y Int J Mol Sci 2018[Feb]; 19 (2): ä PMID29415457show ga Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the underlying molecular mechanisms remained unclear. The breakthrough discovery that the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes. Our group and others showed that altered ZnT8 function may be involved in the pathogenesis of type 2 diabetes, indicating that the precise control of zinc homeostasis is crucial for maintaining health and preventing various diseases, including lifestyle-associated diseases. Recently, the role of the zinc transporter ZIP13 in the regulation of beige adipocyte biogenesis was clarified, which indicated zinc homeostasis regulation as a possible therapeutic target for obesity and metabolic syndrome. Here we review advances in the role of zinc homeostasis in the pathophysiology of diabetes, and propose that inadequate zinc distribution may affect the onset of diabetes and metabolic diseases by regulating various critical biological events. äRole of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity (epmc).pdf DeepDyve Pubget Overpricing