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10.3390/ijms19020470 http://scihub22266oqcxt.onion/10.3390/ijms19020470 C5855692!5855692!29401748     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (2): ä Nephropedia Template TP {{tp|p=29401748|t=2018. Key Aspects of Nucleic Acid Library Design for in Vitro Selection |pdf=|usr=}}{{29401748}} gab.com Text Key Aspects of Nucleic Acid Library Design for in Vitro Selection JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29401748 #FOAvip Nucleic acid aptamers capable of selectively recognizing their target molecules have nowadays been established as powerful and tunable tools for biospecific applications, be it therapeutics, drug delivery systems or biosensors. It is now generally acknowledged that in vitro selection enables one to generate aptamers to almost any target of interest. However, the success of selection and the affinity of the resulting aptamers depend to a large extent on the nature and design of an initial random nucleic acid library. In this review, we summarize and discuss the most important features of the design of nucleic acid libraries for in vitro selection such as the nature of the library (DNA, RNA or modified nucleotides), the length of a randomized region and the presence of fixed sequences. We also compare and contrast different randomization strategies and consider computer methods of library design and some other aspects. Twit Text FOAVip Key Aspects of Nucleic Acid Library Design for in Vitro Selection ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29401748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29401748 #FOAvip English Wikipedia <ref>{{Cite pmid|29401748}}</ref> Key Aspects of Nucleic Acid Library Design for in Vitro Selection #MMPMID29401748 Vorobyeva MA; Davydova AS; Vorobjev PE; Pyshnyi DV; Venyaminova AG Int J Mol Sci 2018[Feb]; 19 (2): ä PMID29401748show ga Nucleic acid aptamers capable of selectively recognizing their target molecules have nowadays been established as powerful and tunable tools for biospecific applications, be it therapeutics, drug delivery systems or biosensors. It is now generally acknowledged that in vitro selection enables one to generate aptamers to almost any target of interest. However, the success of selection and the affinity of the resulting aptamers depend to a large extent on the nature and design of an initial random nucleic acid library. In this review, we summarize and discuss the most important features of the design of nucleic acid libraries for in vitro selection such as the nature of the library (DNA, RNA or modified nucleotides), the length of a randomized region and the presence of fixed sequences. We also compare and contrast different randomization strategies and consider computer methods of library design and some other aspects. äKey Aspects of Nucleic Acid Library Design for in Vitro Selection (epmc).pdf DeepDyve Pubget Overpricing