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10.3390/ijms19020450

http://scihub22266oqcxt.onion/10.3390/ijms19020450
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suck abstract from ncbi


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pmid29393911      Int+J+Mol+Sci 2018 ; 19 (2): ä
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  • The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression #MMPMID29393911
  • Escalona RM; Chan E; Kannourakis G; Findlay JK; Ahmed N
  • Int J Mol Sci 2018[Feb]; 19 (2): ä PMID29393911show ga
  • Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated with chemoresistance. The metzincin family of metalloproteinases is enzymes involved in matrix remodeling in response to normal physiological changes and diseased states. Recently, there has been a mounting awareness of these proteinases and their endogenous inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), as superb modulators of cellular communication and signaling regulating key biological processes in cancer progression. This review investigates the role of metzincins and their inhibitors in ovarian cancer. We propose that understanding the metzincins and TIMP biology in ovarian cancer may provide valuable insights in combating ovarian cancer progression and chemoresistance-mediated recurrence in patients.
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