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10.3390/ijms19020376 http://scihub22266oqcxt.onion/10.3390/ijms19020376 C5855598!5855598!29373547     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (2): ä Nephropedia Template TP {{tp|p=29373547|t=2018. The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation |pdf=|usr=}}{{29373547}} gab.com Text The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29373547 #FOAvip Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been shown to exert potent pharmacological effects, especially an immunosuppressive effect in the treatment of rheumatoid arthritis (RA). However, its multiorgan toxicity prevents it from being widely used in clinical practice. Recently, several attempts are being performed to reduce TP toxicity. In this review, recent progress in the use of TP for RA, including its pharmacological effects and toxicity, is summarized. Meanwhile, strategies relying on chemical structural modifications, innovative delivery systems, and drug combinations to alleviate the disadvantages of TP are also reviewed. Furthermore, we also discuss the challenges and perspectives in their clinical translation. Twit Text FOAVip The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29373547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29373547 #FOAvip English Wikipedia <ref>{{Cite pmid|29373547}}</ref> The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation #MMPMID29373547 Fan D; Guo Q; Shen J; Zheng K; Lu C; Zhang G; Lu A; He X Int J Mol Sci 2018[Feb]; 19 (2): ä PMID29373547show ga Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been shown to exert potent pharmacological effects, especially an immunosuppressive effect in the treatment of rheumatoid arthritis (RA). However, its multiorgan toxicity prevents it from being widely used in clinical practice. Recently, several attempts are being performed to reduce TP toxicity. In this review, recent progress in the use of TP for RA, including its pharmacological effects and toxicity, is summarized. Meanwhile, strategies relying on chemical structural modifications, innovative delivery systems, and drug combinations to alleviate the disadvantages of TP are also reviewed. Furthermore, we also discuss the challenges and perspectives in their clinical translation. äThe Effect of Triptolide in Rheumatoid Arthritis: From Basic Research (epmc).pdf DeepDyve Pubget Overpricing