Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29525767
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Effectiveness of evidence-based treatments of fetal alcohol spectrum disorders in
children and adolescents: a systematic review protocol
#MMPMID29525767
Singal D
; Menard C
; Neilson CJ
; Brownell M
; Hanlon-Dearman A
; Chudley A
; Zarychanski R
; Abou-Setta A
BMJ Open
2018[Mar]; 8
(3
): e013775
PMID29525767
show ga
INTRODUCTION: The aim of this paper is to provide a protocol for a systematic
review assessing the effectiveness of evidence from randomised controlled trials
comparing fetal alcohol spectrum disorders pharmacological and
non-pharmacological interventions with placebo/dummy interventions or usual
standards of care in children and adolescents (<18 years old). METHODS AND
ANALYSIS: The following electronic databases will be searched: Medline (Ovid),
Cumulative Index of Nursing and Allied Health Plus with Full text (EBSCO),
Cochrane Central Register of Controlled Trials (Cochrane Library-Wiley), PsycINFO
(ProQuest) and Proquest DissertationsandTheses will be searched from inception to
March 2017 for relevant citations of published trials using individualised search
strategies prepared for database. We will also search the reference lists of
relevant articles and conference proceedings. Two reviewers will independently
assess each study against predetermined inclusion/exclusion criteria and extract
data including population characteristics, types and duration of interventions
and outcomes from included trials. Internal validity will be assessed using the
Cochrane Risk of Bias Tool. Primary outcome measures will be improvements in
symptoms, including: hyperactivity, impulsivity and attention as measured by
standard rating scales. Secondary outcome measures will include improvements in
physical and mental health domains, as well as cognitive, behavioural, social and
educational skills as measured by rating scales, standardised psychometric tests
of IQ and memory, grade repetition, literacy tests and diagnosis of mental health
disorder. ETHICS AND DISSEMINATION: Ethical approval will not be obtained since
it is not required for systematic reviews as there are no concerns regarding
patient privacy. The results of this review will be disseminated through
publication in a peer-review journal and presented at relevant conferences.
PROSPERO REGISTRATION NUMBER: CRD42013005996.
free
free
free
