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10.1007/164_2016_39 http://scihub22266oqcxt.onion/10.1007/164_2016_39 C5855116!5855116 !27783269     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27783269 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Handb+Exp+Pharmacol 2017 ; 240 (ä): 71-101 Nephropedia Template TP {{tp|p=27783269 |t=2017. Anion Channels of Mitochondria |pdf=|usr=}}{{27783269 }} gab.com Text Anion Channels of Mitochondria JO: Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27783269 #FOAvip Mitochondria are the "power house" of a cell continuously generating ATP to ensure its proper functioning. The constant production of ATP via oxidative phosphorylation demands a large electrochemical force that drives protons across the highly selective and low-permeable mitochondrial inner membrane. Besides the conventional role of generating ATP, mitochondria also play an active role in calcium signaling, generation of reactive oxygen species (ROS), stress responses, and regulation of cell-death pathways. Deficiencies in these functions result in several pathological disorders like aging, cancer, diabetes, neurodegenerative and cardiovascular diseases. A plethora of ion channels and transporters are present in the mitochondrial inner and outer membranes which work in concert to preserve the ionic equilibrium of a cell for the maintenance of cell integrity, in physiological as well as pathophysiological conditions. For, e.g., mitochondrial cation channels K(ATP) and BK(Ca) play a significant role in cardioprotection from ischemia-reperfusion injury. In addition to the cation channels, mitochondrial anion channels are equally essential, as they aid in maintaining electro-neutrality by regulating the cell volume and pH. This chapter focusses on the information on molecular identity, structure, function, and physiological relevance of mitochondrial chloride channels such as voltage dependent anion channels (VDACs), uncharacterized mitochondrial inner membrane anion channels (IMACs), chloride intracellular channels (CLIC) and the aspects of forthcoming chloride channels. Twit Text FOAVip Anion Channels of Mitochondria ????Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27783269 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27783269 #FOAvip English Wikipedia <ref>{{Cite pmid|27783269 }}</ref> Anion Channels of Mitochondria #MMPMID27783269 Ponnalagu D ; Singh H Handb Exp Pharmacol 2017[]; 240 (ä): 71-101 PMID27783269 show ga Mitochondria are the "power house" of a cell continuously generating ATP to ensure its proper functioning. The constant production of ATP via oxidative phosphorylation demands a large electrochemical force that drives protons across the highly selective and low-permeable mitochondrial inner membrane. Besides the conventional role of generating ATP, mitochondria also play an active role in calcium signaling, generation of reactive oxygen species (ROS), stress responses, and regulation of cell-death pathways. Deficiencies in these functions result in several pathological disorders like aging, cancer, diabetes, neurodegenerative and cardiovascular diseases. A plethora of ion channels and transporters are present in the mitochondrial inner and outer membranes which work in concert to preserve the ionic equilibrium of a cell for the maintenance of cell integrity, in physiological as well as pathophysiological conditions. For, e.g., mitochondrial cation channels K(ATP) and BK(Ca) play a significant role in cardioprotection from ischemia-reperfusion injury. In addition to the cation channels, mitochondrial anion channels are equally essential, as they aid in maintaining electro-neutrality by regulating the cell volume and pH. This chapter focusses on the information on molecular identity, structure, function, and physiological relevance of mitochondrial chloride channels such as voltage dependent anion channels (VDACs), uncharacterized mitochondrial inner membrane anion channels (IMACs), chloride intracellular channels (CLIC) and the aspects of forthcoming chloride channels. |Animals [MESH] |Chloride Channels/*physiology [MESH] |Humans [MESH] |Mitochondria/*metabolism [MESH] |Mitochondrial Membrane Transport Proteins/physiology [MESH] |Mitochondrial Permeability Transition Pore [MESH]Anion Channels of Mitochondria (epmc).pdf DeepDyve Pubget Overpricing