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10.1016/j.redox.2018.02.024 http://scihub22266oqcxt.onion/10.1016/j.redox.2018.02.024 C5854917!5854917!29547847     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Redox+Biol 2018 ; 16 (ä): 248-54 Nephropedia Template TP {{tp|p=29547847|t=2018. Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling |pdf=|usr=}}{{29547847}} gab.com Text Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling JO: Redox Biol http://www.kidney.de/pget.php?&tw=1&pmid=29547847 #FOAvip Early podocyte loss is characteristic of chronic kidney diseases (CKD) in obesity and diabetes. Since treatments for hyperglycemia and hypertension do not prevent podocyte loss, there must be additional factors causing podocyte depletion. The role of oxidative stress has been implicated in CKD but it is not known how exactly free radicals affect podocyte physiology. To assess this relationship, we investigated the effects of lipid radicals on podocytes, as lipid peroxidation is a major form of oxidative stress in diabetes. We found that lipid radicals govern changes in podocyte homeostasis through redox sensitive RhoA signaling: lipid radicals inhibit migration and cause loss of F-actin fibers. These effects were prevented by mutating the redox sensitive cysteines of RhoA. We therefore suggest that in diseases associated with increased lipid peroxidation, lipid radicals can determine podocyte function with potentially pathogenic consequences for kidney physiology. Twit Text FOAVip Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling ????Redox Biol http://www.kidney.de/pget.php?&tw=1&pmid=29547847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29547847 #FOAvip English Wikipedia <ref>{{Cite pmid|29547847}}</ref> Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling #MMPMID29547847 Kruger C; Burke SJ; Collier JJ; Nguyen TT; Salbaum JM; Stadler K Redox Biol 2018[Jun]; 16 (ä): 248-54 PMID29547847show ga Early podocyte loss is characteristic of chronic kidney diseases (CKD) in obesity and diabetes. Since treatments for hyperglycemia and hypertension do not prevent podocyte loss, there must be additional factors causing podocyte depletion. The role of oxidative stress has been implicated in CKD but it is not known how exactly free radicals affect podocyte physiology. To assess this relationship, we investigated the effects of lipid radicals on podocytes, as lipid peroxidation is a major form of oxidative stress in diabetes. We found that lipid radicals govern changes in podocyte homeostasis through redox sensitive RhoA signaling: lipid radicals inhibit migration and cause loss of F-actin fibers. These effects were prevented by mutating the redox sensitive cysteines of RhoA. We therefore suggest that in diseases associated with increased lipid peroxidation, lipid radicals can determine podocyte function with potentially pathogenic consequences for kidney physiology. äLipid peroxidation regulates podocyte migration and cytoskeletal struc(epmc).pdf DeepDyve Pubget Overpricing