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10.1038/s41467-018-03493-5 http://scihub22266oqcxt.onion/10.1038/s41467-018-03493-5 C5854619!5854619!29545616     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29545616|t=2018. Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis |pdf=|usr=}}{{29545616}} gab.com Text Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29545616 #FOAvip Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here we show that during atherogenesis Treg cells lose Foxp3 expression and their immunosuppressive function, leading to the conversion of a fraction of these cells into T follicular helper (Tfh) cells. We show that Tfh cells are pro-atherogenic and that their depletion reduces atherosclerosis. Mechanistically, the conversion of Treg cells to Tfh cells correlates with reduced expression of IL-2R? and pSTAT5 levels and increased expression of IL-6R?. In vitro, incubation of naive T cells with oxLDL prevents their differentiation into Treg cells. Furthermore, injection of lipid-free Apolipoprotein AI (ApoAI) into ApoE?/? mice reduces intracellular cholesterol levels in Treg cells and prevents their conversion into Tfh cells. Together our results suggest that ApoAI, the main protein in high-density lipoprotein particles, modulates the cellular fate of Treg cells and thus influences the immune response during atherosclerosis. Twit Text FOAVip Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29545616 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29545616 #FOAvip English Wikipedia <ref>{{Cite pmid|29545616}}</ref> Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis #MMPMID29545616 Gaddis DE; Padgett LE; Wu R; McSkimming C; Romines V; Taylor AM; McNamara CA; Kronenberg M; Crotty S; Thomas MJ; Sorci-Thomas MG; Hedrick CC Nat Commun 2018[]; 9 (ä): ä PMID29545616show ga Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here we show that during atherogenesis Treg cells lose Foxp3 expression and their immunosuppressive function, leading to the conversion of a fraction of these cells into T follicular helper (Tfh) cells. We show that Tfh cells are pro-atherogenic and that their depletion reduces atherosclerosis. Mechanistically, the conversion of Treg cells to Tfh cells correlates with reduced expression of IL-2R? and pSTAT5 levels and increased expression of IL-6R?. In vitro, incubation of naive T cells with oxLDL prevents their differentiation into Treg cells. Furthermore, injection of lipid-free Apolipoprotein AI (ApoAI) into ApoE?/? mice reduces intracellular cholesterol levels in Treg cells and prevents their conversion into Tfh cells. Together our results suggest that ApoAI, the main protein in high-density lipoprotein particles, modulates the cellular fate of Treg cells and thus influences the immune response during atherosclerosis. äApolipoprotein AI prevents regulatory to follicular helper T cell swit(epmc).pdf DeepDyve Pubget Overpricing