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10.1038/s41467-018-03483-7 http://scihub22266oqcxt.onion/10.1038/s41467-018-03483-7 C5854605!5854605!29545568     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29545568|t=2018. How RNA transcripts coordinate DNA recombination and repair |pdf=|usr=}}{{29545568}} gab.com Text How RNA transcripts coordinate DNA recombination and repair JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29545568 #FOAvip Genetic studies in yeast indicate that RNA transcripts facilitate homology-directed DNA repair in a manner that is dependent on RAD52. The molecular basis for so-called RNA?DNA repair, however, remains unknown. Using reconstitution assays, we demonstrate that RAD52 directly cooperates with RNA as a sequence-directed ribonucleoprotein complex to promote two related modes of RNA?DNA repair. In a RNA-bridging mechanism, RAD52 assembles recombinant RNA?DNA hybrids that coordinate synapsis and ligation of homologous DNA breaks. In an RNA-templated mechanism, RAD52-mediated RNA?DNA hybrids enable reverse transcription-dependent RNA-to-DNA sequence transfer at DNA breaks that licenses subsequent DNA recombination. Notably, we show that both mechanisms of RNA?DNA repair are promoted by transcription of a homologous DNA template in trans. In summary, these data elucidate how RNA transcripts cooperate with RAD52 to coordinate homology-directed DNA recombination and repair in the absence of a DNA donor, and demonstrate a direct role for transcription in RNA?DNA repair. Twit Text FOAVip How RNA transcripts coordinate DNA recombination and repair ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29545568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29545568 #FOAvip English Wikipedia <ref>{{Cite pmid|29545568}}</ref> How RNA transcripts coordinate DNA recombination and repair #MMPMID29545568 McDevitt S; Rusanov T; Kent T; Chandramouly G; Pomerantz RT Nat Commun 2018[]; 9 (ä): ä PMID29545568show ga Genetic studies in yeast indicate that RNA transcripts facilitate homology-directed DNA repair in a manner that is dependent on RAD52. The molecular basis for so-called RNA?DNA repair, however, remains unknown. Using reconstitution assays, we demonstrate that RAD52 directly cooperates with RNA as a sequence-directed ribonucleoprotein complex to promote two related modes of RNA?DNA repair. In a RNA-bridging mechanism, RAD52 assembles recombinant RNA?DNA hybrids that coordinate synapsis and ligation of homologous DNA breaks. In an RNA-templated mechanism, RAD52-mediated RNA?DNA hybrids enable reverse transcription-dependent RNA-to-DNA sequence transfer at DNA breaks that licenses subsequent DNA recombination. Notably, we show that both mechanisms of RNA?DNA repair are promoted by transcription of a homologous DNA template in trans. In summary, these data elucidate how RNA transcripts cooperate with RAD52 to coordinate homology-directed DNA recombination and repair in the absence of a DNA donor, and demonstrate a direct role for transcription in RNA?DNA repair. äHow RNA transcripts coordinate DNA recombination and repair (epmc).pdf DeepDyve Pubget Overpricing