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Mast Cells Exhibiting Strong Cytoplasmic Staining for IgE and High Affinity IgE
Receptor are Increased in IgG4-Related Disease
#MMPMID29545608
Nishida K
; Gion Y
; Takeuchi M
; Tanaka T
; Kataoka TR
; Yoshino T
; Sato Y
Sci Rep
2018[Mar]; 8
(1
): 4656
PMID29545608
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Immunoglobulin G4 (IgG4)-related disease is characterized by elevated serum IgG4
levels and increased numbers of IgG4-positive cells. However, its pathogenesis is
not fully understood. We previously suggested that mast cells may play an
important role in IgG4-related disease. In this study, we confirmed the
characteristics of mast cells in IgG4-related lymphadenopathy by using
immunohistochemistry and dual immunofluorescence. We analyzed 23 cases of
IgG4-related lymphadenopathy and compared them with 23 cases of non-specific
lymphoid hyperplasia. The majority of patients with IgG4-related lymphadenopathy
had cervical lesions with involvement of other organs. Immunohistologically, mast
cells with strong cytoplasmic staining for immunoglobulin E and high affinity
immunoglobulin E receptor were significantly increased in IgG4-related
lymphadenopathy as compared to those in non-specific lymphoid hyperplasia (mean:
3.83?±?3.99 cells per high power field and 7.14?±?8.21 cells per high power
field, respectively; P?=?0.007 and P?=?0.011). In addition, dual
immunofluorescence assay showed that immunoglobulin E and high affinity
immunoglobulin E receptor staining exhibited a cytoplasmic granular pattern in
IgG4-related lymphadenopathy, suggesting internalization of the antibodies and
receptors. Our findings showed that mast cell activation might be involved in the
pathogenesis of IgG4-related disease.
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