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10.1126/scitranslmed.aam8475 http://scihub22266oqcxt.onion/10.1126/scitranslmed.aam8475 C5854487!5854487 !29167396     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29167396 &cmd=llinks): Failed to open stream: HTTP request failed! 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Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk |pdf=|usr=}}{{29167396 }} gab.com Text Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29167396 #FOAvip Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on standard antithrombotic/antiplatelet therapies. Although the associations of indolic uremic solutes and vascular wall proteins [such as tissue factor (TF) and aryl hydrocarbon receptor (AHR)] are being defined, the specific mechanisms that drive the thrombotic and bleeding risks are not fully understood. We now present an indolic solute-specific animal model, which focuses on solute-protein interactions and shows that indolic solutes mediate the hyperthrombotic phenotype across all CKD stages in an AHR- and TF-dependent manner. We further demonstrate that AHR regulates TF through STIP1 homology and U-box-containing protein 1 (STUB1). As a ubiquitin ligase, STUB1 dynamically interacts with and degrades TF through ubiquitination in the uremic milieu. TF regulation by STUB1 is supported in humans by an inverse relationship of STUB1 and TF expression and reduced STUB1-TF interaction in uremic vessels. Genetic or pharmacological manipulation of STUB1 in vascular smooth muscle cells inhibited thrombosis in flow loops. STUB1 perturbations reverted the uremic hyperthrombotic phenotype without prolonging the bleeding time, in contrast to heparin, the standard-of-care antithrombotic in CKD patients. Our work refines the thrombosis axis (STUB1 is a mediator of indolic solute-AHR-TF axis) and expands the understanding of the interconnected relationships driving the fragile thrombotic state in CKD. It also establishes a means of minimizing the uremic hyperthrombotic phenotype without altering the hemostatic balance, a long-sought-after combination in CKD patients. Twit Text FOAVip Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29167396 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29167396 #FOAvip English Wikipedia <ref>{{Cite pmid|29167396 }}</ref> Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk #MMPMID29167396 Shashar M ; Belghasem ME ; Matsuura S ; Walker J ; Richards S ; Alousi F ; Rijal K ; Kolachalama VB ; Balcells M ; Odagi M ; Nagasawa K ; Henderson JM ; Gautam A ; Rushmore R ; Francis J ; Kirchhofer D ; Kolandaivelu K ; Sherr DH ; Edelman ER ; Ravid K ; Chitalia VC Sci Transl Med 2017[Nov]; 9 (417 ): ä PMID29167396 show ga Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on standard antithrombotic/antiplatelet therapies. Although the associations of indolic uremic solutes and vascular wall proteins [such as tissue factor (TF) and aryl hydrocarbon receptor (AHR)] are being defined, the specific mechanisms that drive the thrombotic and bleeding risks are not fully understood. We now present an indolic solute-specific animal model, which focuses on solute-protein interactions and shows that indolic solutes mediate the hyperthrombotic phenotype across all CKD stages in an AHR- and TF-dependent manner. We further demonstrate that AHR regulates TF through STIP1 homology and U-box-containing protein 1 (STUB1). As a ubiquitin ligase, STUB1 dynamically interacts with and degrades TF through ubiquitination in the uremic milieu. TF regulation by STUB1 is supported in humans by an inverse relationship of STUB1 and TF expression and reduced STUB1-TF interaction in uremic vessels. Genetic or pharmacological manipulation of STUB1 in vascular smooth muscle cells inhibited thrombosis in flow loops. STUB1 perturbations reverted the uremic hyperthrombotic phenotype without prolonging the bleeding time, in contrast to heparin, the standard-of-care antithrombotic in CKD patients. Our work refines the thrombosis axis (STUB1 is a mediator of indolic solute-AHR-TF axis) and expands the understanding of the interconnected relationships driving the fragile thrombotic state in CKD. It also establishes a means of minimizing the uremic hyperthrombotic phenotype without altering the hemostatic balance, a long-sought-after combination in CKD patients. |Analysis of Variance [MESH] |Animals [MESH] |Female [MESH] |Hemorrhage/enzymology/*metabolism/pathology [MESH] |Male [MESH] |Mice [MESH] |Renal Insufficiency, Chronic/enzymology/metabolism/pathology [MESH] |Thrombosis/enzymology/*metabolism/pathology [MESH] |Ubiquitin-Protein Ligases/genetics/*metabolism [MESH]Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic p(epmc).pdf DeepDyve Pubget Overpricing