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10.1371/journal.ppat.1006839

http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006839
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C5854428!5854428!29543893
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suck abstract from ncbi

pmid29543893      PLoS+Pathog 2018 ; 14 (3): ä
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  • Viral manipulation of STAT3: Evade, exploit, and injure #MMPMID29543893
  • Roca Suarez AA; Van Renne N; Baumert TF; Lupberger J
  • PLoS Pathog 2018[Mar]; 14 (3): ä PMID29543893show ga
  • Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.
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