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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2018 ; 13
(3
): e0194218
Nephropedia Template TP
gab.com Text
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English Wikipedia
Removal of the blue component of light significantly decreases retinal damage
after high intensity exposure
#MMPMID29543853
Vicente-Tejedor J
; Marchena M
; Ramírez L
; García-Ayuso D
; Gómez-Vicente V
; Sánchez-Ramos C
; de la Villa P
; Germain F
PLoS One
2018[]; 13
(3
): e0194218
PMID29543853
show ga
Light causes damage to the retina (phototoxicity) and decreases photoreceptor
responses to light. The most harmful component of visible light is the blue
wavelength (400-500 nm). Different filters have been tested, but so far all of
them allow passing a lot of this wavelength (70%). The aim of this work has been
to prove that a filter that removes 94% of the blue component may protect the
function and morphology of the retina significantly. Three experimental groups
were designed. The first group was unexposed to light, the second one was exposed
and the third one was exposed and protected by a blue-blocking filter. Light
damage was induced in young albino mice (p30) by exposing them to white light of
high intensity (5,000 lux) continuously for 7 days. Short wavelength light
filters were used for light protection. The blue component was removed (94%) from
the light source by our filter. Electroretinographical recordings were performed
before and after light damage. Changes in retinal structure were studied using
immunohistochemistry, and TUNEL labeling. Also, cells in the outer nuclear layer
were counted and compared among the three different groups. Functional visual
responses were significantly more conserved in protected animals (with the
blue-blocking filter) than in unprotected animals. Also, retinal structure was
better kept and photoreceptor survival was greater in protected animals, these
differences were significant in central areas of the retina. Still, functional
and morphological responses were significantly lower in protected than in
unexposed groups. In conclusion, this blue-blocking filter decreases
significantly photoreceptor damage after exposure to high intensity light.
Actually, our eyes are exposed for a very long time to high levels of blue light
(screens, artificial light LED, neons?). The potential damage caused by blue
light can be palliated.
|Animals
[MESH]
|Color
[MESH]
|Electroretinography
[MESH]
|Eye Injuries/diagnosis/etiology/*prevention & control
[MESH]
free
free
free
