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Investigation of tissue cellularity at the tip of the core biopsy needle with
optical coherence tomography
#MMPMID29552405
Iftimia N
; Park J
; Maguluri G
; Krishnamurthy S
; McWatters A
; Sabir SH
Biomed Opt Express
2018[Feb]; 9
(2
): 694-704
PMID29552405
show ga
We report the development and the pre-clinical testing of a new technology based
on optical coherence tomography (OCT) for investigating tissue composition at the
tip of the core biopsy needle. While ultrasound, computed tomography, and
magnetic resonance imaging are routinely used to guide needle placement within a
tumor, they still do not provide the resolution needed to investigate tissue
cellularity (ratio between viable tumor and benign stroma) at the needle tip
prior to taking a biopsy core. High resolution OCT imaging, however, can be used
to investigate tissue morphology at the micron scale, and thus to determine if
the biopsy core would likely have the expected composition. Therefore, we
implemented this capability within a custom-made biopsy gun and evaluated its
capability for a correct estimation of tumor tissue cellularity. A pilot study on
a rabbit model of soft tissue cancer has shown the capability of this technique
to provide correct evaluation of tumor tissue cellularity in over 85% of the
cases. These initial results indicate the potential benefit of the OCT-based
approach for improving the success of the core biopsy procedures.
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