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10.1186/s12944-018-0698-4 http://scihub22266oqcxt.onion/10.1186/s12944-018-0698-4 C5853053!5853053 !29540222     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29540222 &cmd=llinks): Failed to open stream: HTTP request failed! 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Lipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H E L P -apheresis study |pdf=|usr=}}{{29540222 }} gab.com Text Lipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H E L P -apheresis study JO: Lipids Health Dis http://www.kidney.de/pget.php?&tw=1&pmid=29540222 #FOAvip BACKGROUND: Preeclampsia is a life-threatening disease in pregnancy, and its complex pathomechanisms are poorly understood. In preeclampsia, lipid metabolism is substantially altered. In late onset preeclampsia, remnant removal disease like lipoprotein profiles have been observed. Lipid apheresis is currently being explored as a possible therapeutic approach to prolong preeclamptic pregnancies. Here, apheresis-induced changes in serum lipid parameters are analyzed in detail and their implications for preeclamptic lipid metabolism are discussed. METHODS: In the Freiburg H.E.L.P.-Apheresis Study, 6 early onset preeclamptic patients underwent repeated apheresis treatments. Serum lipids pre- and post-apheresis and during lipid rebound were analyzed in depth via ultracentrifugation to yield lipoprotein subclasses. RESULTS: The net elimination of Apolipoprotein B and plasma lipids was lower than theoretically expected. Lipids returned to previous pre-apheresis levels before the next apheresis even though apheresis was repeated within 2.9?±?1.2 days. Apparent fractional catabolic rates and synthetic rates were substantially elevated, with fractional catabolic rates for Apolipoprotein B / LDL-cholesterol being 0.7?±?0.3 / 0.4?±?0.2 [day(-?1)] and synthetic rates being 26?±?8 / 17?±?8 [mg*kg(-?1)*day(-?1)]. The distribution of LDL-subclasses after apheresis shifted to larger buoyant LDL, while intermediate-density lipoprotein-levels remained unaffected, supporting the notion of an underlying remnant removal disorder in preeclampsia. CONCLUSION: Lipid metabolism seems to be highly accelerated in preeclampsia, likely outbalancing remnant removal mechanisms. Since cholesterol-rich lipoprotein remnants are able to accumulate in the vessel wall, remnant lipoproteins may contribute to the severe endothelial dysfunction observed in preeclampsia. TRIAL REGISTRATION: ClinicalTrails.gov, NCT01967355 . Twit Text FOAVip Lipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H E L P -apheresis study ????Lipids Health Dis http://www.kidney.de/pget.php?&tw=1&pmid=29540222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29540222 #FOAvip English Wikipedia <ref>{{Cite pmid|29540222 }}</ref> Lipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H E L P -apheresis study #MMPMID29540222 Contini C ; Jansen M ; König B ; Markfeld-Erol F ; Kunze M ; Zschiedrich S ; Massing U ; Merfort I ; Prömpeler H ; Pecks U ; Winkler K ; Pütz G Lipids Health Dis 2018[Mar]; 17 (1 ): 49 PMID29540222 show ga BACKGROUND: Preeclampsia is a life-threatening disease in pregnancy, and its complex pathomechanisms are poorly understood. In preeclampsia, lipid metabolism is substantially altered. In late onset preeclampsia, remnant removal disease like lipoprotein profiles have been observed. Lipid apheresis is currently being explored as a possible therapeutic approach to prolong preeclamptic pregnancies. Here, apheresis-induced changes in serum lipid parameters are analyzed in detail and their implications for preeclamptic lipid metabolism are discussed. METHODS: In the Freiburg H.E.L.P.-Apheresis Study, 6 early onset preeclamptic patients underwent repeated apheresis treatments. Serum lipids pre- and post-apheresis and during lipid rebound were analyzed in depth via ultracentrifugation to yield lipoprotein subclasses. RESULTS: The net elimination of Apolipoprotein B and plasma lipids was lower than theoretically expected. Lipids returned to previous pre-apheresis levels before the next apheresis even though apheresis was repeated within 2.9?±?1.2 days. Apparent fractional catabolic rates and synthetic rates were substantially elevated, with fractional catabolic rates for Apolipoprotein B / LDL-cholesterol being 0.7?±?0.3 / 0.4?±?0.2 [day(-?1)] and synthetic rates being 26?±?8 / 17?±?8 [mg*kg(-?1)*day(-?1)]. The distribution of LDL-subclasses after apheresis shifted to larger buoyant LDL, while intermediate-density lipoprotein-levels remained unaffected, supporting the notion of an underlying remnant removal disorder in preeclampsia. CONCLUSION: Lipid metabolism seems to be highly accelerated in preeclampsia, likely outbalancing remnant removal mechanisms. Since cholesterol-rich lipoprotein remnants are able to accumulate in the vessel wall, remnant lipoproteins may contribute to the severe endothelial dysfunction observed in preeclampsia. TRIAL REGISTRATION: ClinicalTrails.gov, NCT01967355 . |*Lipid Metabolism [MESH] |Adult [MESH] |Apolipoproteins B/blood [MESH] |Blood Component Removal [MESH] |Cholesterol, LDL/*blood [MESH] |Cholesterol/*blood [MESH] |Female [MESH] |Humans [MESH] |Lipoproteins/*blood [MESH] |Pre-Eclampsia/*blood/pathology [MESH] |Pregnancy [MESH]Lipoprotein turnover and possible remnant accumulation in preeclampsia(epmc).pdf DeepDyve Pubget Overpricing