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10.1038/s41389-018-0034-x http://scihub22266oqcxt.onion/10.1038/s41389-018-0034-x C5852963!5852963!29540752     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2018 ; 7 (3): ä Nephropedia Template TP {{tp|p=29540752|t=2018. Double agents: genes with both oncogenic and tumor-suppressor functions |pdf=|usr=}}{{29540752}} gab.com Text Double agents: genes with both oncogenic and tumor-suppressor functions JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29540752 #FOAvip The role of genetic components in cancer development is an area of interest for cancer biologists in general. Intriguingly, some genes have both oncogenic and tumor-suppressor functions. In this study, we systematically identified these genes through database search and text mining. We find that most of them are transcription factors or kinases and exhibit dual biological functions, e.g., that they both positively and negatively regulate transcription in cells. Some cancer types such as leukemia are over-represented by them, whereas some common cancer types such as lung cancer are under-represented by them. Across 12 major cancer types, while their genomic mutation patterns are similar to that of oncogenes, their expression patterns are more similar to that of tumor-suppressor genes. Their expression profile in six human organs propose that they mainly function as tumor suppressor in normal tissue. Our network analyses further show they have higher network degrees than both oncogenes and tumor-suppressor genes and thus tend to be the hub genes in the protein?protein interaction network. Our mutation, expression spectrum, and network analyses might help explain why some cancer types are specifically associated with them. Finally, our results suggest that the functionally altering mutations in ?double-agent? genes and oncogenes are the main driving force in cancer development, because non-silent mutations are biasedly distributed toward these two gene sets across all 12 major cancer types. Twit Text FOAVip Double agents: genes with both oncogenic and tumor-suppressor functions ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29540752 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29540752 #FOAvip English Wikipedia <ref>{{Cite pmid|29540752}}</ref> Double agents: genes with both oncogenic and tumor-suppressor functions #MMPMID29540752 Shen L; Shi Q; Wang W Oncogenesis 2018[Mar]; 7 (3): ä PMID29540752show ga The role of genetic components in cancer development is an area of interest for cancer biologists in general. Intriguingly, some genes have both oncogenic and tumor-suppressor functions. In this study, we systematically identified these genes through database search and text mining. We find that most of them are transcription factors or kinases and exhibit dual biological functions, e.g., that they both positively and negatively regulate transcription in cells. Some cancer types such as leukemia are over-represented by them, whereas some common cancer types such as lung cancer are under-represented by them. Across 12 major cancer types, while their genomic mutation patterns are similar to that of oncogenes, their expression patterns are more similar to that of tumor-suppressor genes. Their expression profile in six human organs propose that they mainly function as tumor suppressor in normal tissue. Our network analyses further show they have higher network degrees than both oncogenes and tumor-suppressor genes and thus tend to be the hub genes in the protein?protein interaction network. Our mutation, expression spectrum, and network analyses might help explain why some cancer types are specifically associated with them. Finally, our results suggest that the functionally altering mutations in ?double-agent? genes and oncogenes are the main driving force in cancer development, because non-silent mutations are biasedly distributed toward these two gene sets across all 12 major cancer types. äDouble agents: genes with both oncogenic and tumor-suppressor function(epmc).pdf DeepDyve Pubget Overpricing