Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29540152
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29540152
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Nephrol
2018 ; 19
(1
): 64
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Successful treatment of recurrent immunoglobulin a nephropathy using steroid
pulse therapy plus tonsillectomy 10 years after kidney transplantation: a case
presentation
#MMPMID29540152
Katsumata H
; Yamamoto I
; Komatsuzaki Y
; Kawabe M
; Okabayashi Y
; Yamakawa T
; Katsuma A
; Nakada Y
; Kobayashi A
; Tanno Y
; Miki J
; Yamada H
; Ohkido I
; Tsuboi N
; Yamamoto H
; Yokoo T
BMC Nephrol
2018[Mar]; 19
(1
): 64
PMID29540152
show ga
BACKGROUND: Both prevention and treatment of recurrent immunoglobulin A
nephropathy (IgAN) in kidney transplant recipients are important since recurrent
IgAN seems to affect long-term graft survival. We present here a case of
recurrent IgAN that was successfully treated using steroid pulse therapy plus
tonsillectomy 10 years after kidney transplantation. CASE PRESENTATION: A
46-year-old male was admitted for an episode biopsy with a serum creatinine level
of 1.8 mg/dl and proteinuria (0.7 g/day). Histological features showed recurrent
IgAN (only focal segmental mesangial proliferation) and severe arteriolar
hyalinosis partly associated with calcineurin inhibitor toxicity, with limited
interstitial fibrosis and tubular atrophy (5%) (IF/TA) 8 years after
transplantation. Sodium restriction and conversion from cyclosporine to
tacrolimus successfully reduced his proteinuria to the level of 0.15 g/day.
However, 2 years later, his proteinuria increased again (1.0 g/day) and a second
episode biopsy showed global mesangial proliferation with glomerular
endocapillary and extracapillary proliferation accompanied by progressive IF/TA
(20%). The steroid pulse therapy plus tonsillectomy successfully decreased his
proteinuria and he achieved clinical remission 3 years after this treatment.
CONCLUSION: This case, presented with a review of relevant literature,
demonstrates the difficulty and importance of the treatment of recurrent IgAN and
calcineurin inhibitor arteriolopathy, especially in long-term kidney allograft
management.