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10.1093/cvr/cvx227 http://scihub22266oqcxt.onion/10.1093/cvr/cvx227 C5852629!5852629 !29186414     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29186414 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cardiovasc+Res 2018 ; 114 (2 ): 291-299 Nephropedia Template TP {{tp|p=29186414 |t=2018. Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice |pdf=|usr=}}{{29186414 }} gab.com Text Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice JO: Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=29186414 #FOAvip AIMS: Cardiac inflammation has been suggested to be regulated by the sympathetic nervous system (SNS). However, due to the lack of methodology to surgically eliminate the myocardial SNS in mice, neuronal control of cardiac inflammation remains ill-defined. Here, we report a procedure for local cardiac sympathetic denervation in mice and tested its effect in a mouse model of heart failure post-myocardial infarction. METHODS AND RESULTS: Upon preparation of the carotid bifurcation, the right and the left superior cervical ganglia were localized and their pre- and postganglionic branches dissected before removal of the ganglion. Ganglionectomy led to an almost entire loss of myocardial sympathetic innervation in the left ventricular anterior wall. When applied at the time of myocardial infarction (MI), cardiac sympathetic denervation did not affect acute myocardial damage and infarct size. In contrast, cardiac sympathetic denervation significantly attenuated chronic consequences of MI, including myocardial inflammation, myocyte hypertrophy, and overall cardiac dysfunction. CONCLUSION: These data suggest a critical role for local sympathetic control of cardiac inflammation. Our model of myocardial sympathetic denervation in mice should prove useful to further dissect the molecular mechanisms underlying cardiac neural control. Twit Text FOAVip Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice ????Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=29186414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29186414 #FOAvip English Wikipedia <ref>{{Cite pmid|29186414 }}</ref> Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice #MMPMID29186414 Ziegler KA ; Ahles A ; Wille T ; Kerler J ; Ramanujam D ; Engelhardt S Cardiovasc Res 2018[Feb]; 114 (2 ): 291-299 PMID29186414 show ga AIMS: Cardiac inflammation has been suggested to be regulated by the sympathetic nervous system (SNS). However, due to the lack of methodology to surgically eliminate the myocardial SNS in mice, neuronal control of cardiac inflammation remains ill-defined. Here, we report a procedure for local cardiac sympathetic denervation in mice and tested its effect in a mouse model of heart failure post-myocardial infarction. METHODS AND RESULTS: Upon preparation of the carotid bifurcation, the right and the left superior cervical ganglia were localized and their pre- and postganglionic branches dissected before removal of the ganglion. Ganglionectomy led to an almost entire loss of myocardial sympathetic innervation in the left ventricular anterior wall. When applied at the time of myocardial infarction (MI), cardiac sympathetic denervation did not affect acute myocardial damage and infarct size. In contrast, cardiac sympathetic denervation significantly attenuated chronic consequences of MI, including myocardial inflammation, myocyte hypertrophy, and overall cardiac dysfunction. CONCLUSION: These data suggest a critical role for local sympathetic control of cardiac inflammation. Our model of myocardial sympathetic denervation in mice should prove useful to further dissect the molecular mechanisms underlying cardiac neural control. |*Ganglionectomy [MESH] |*Myocardium/immunology/metabolism/pathology [MESH] |Animals [MESH] |Heart Failure/immunology/pathology/physiopathology/*prevention & control [MESH] |Heart Ventricles/immunology/*innervation/metabolism/pathology [MESH] |Humans [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Myocardial Infarction/*complications [MESH] |Myocarditis/immunology/pathology/physiopathology/*prevention & control [MESH] |Neuroimmunomodulation [MESH] |Superior Cervical Ganglion/physiopathology/*surgery [MESH]Local sympathetic denervation attenuates myocardial inflammation and i(epmc).pdf DeepDyve Pubget Overpricing