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10.3390/genes9020058 http://scihub22266oqcxt.onion/10.3390/genes9020058 C5852554!5852554!29364168     free     free     free       Genes+(Basel) 2018 ; 9 (2): ä Nephropedia Template TP {{tp|p=29364168|t=2018. Renal Tubule Repair: Is Wnt/?-Catenin a Friend or Foe?|pdf=|usr=}}{{29364168}} gab.com Text Renal Tubule Repair: Is Wnt/ -Catenin a Friend or Foe JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29364168 #FOAvip Wnt/?-catenin signaling is extremely important for proper kidney development. This pathway is also upregulated in injured renal tubular epithelia, both in acute kidney injury and chronic kidney disease. The renal tubular epithelium is an important target of kidney injury, and its response (repair versus persistent injury) is critical for determining whether tubulointerstitial fibrosis, the hallmark of chronic kidney disease, develops. This review discusses how Wnt/?-catenin signaling in the injured tubular epithelia promotes either repair or fibrosis after kidney injury. There is data suggesting that epithelial Wnt/?-catenin signaling is beneficial in acute kidney injury and important in tubular progenitors responsible for epithelial repair. The role of Wnt/?-catenin signaling in chronically injured epithelia is less clear. There is convincing data that Wnt/?-catenin signaling in interstitial fibroblasts and pericytes contributes to the extracellular matrix accumulation that defines fibrosis. However, some recent studies question whether Wnt/?-catenin signaling in chronically injured epithelia actually promotes fibrosis or repair. Twit Text FOAVip Renal Tubule Repair: Is Wnt/ -Catenin a Friend or Foe ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29364168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29364168 #FOAvip English Wikipedia <ref>{{Cite pmid|29364168}}</ref> Renal Tubule Repair: Is Wnt/?-Catenin a Friend or Foe? #MMPMID29364168 Gewin LS Genes (Basel) 2018[Feb]; 9 (2): ä PMID29364168show ga Wnt/?-catenin signaling is extremely important for proper kidney development. This pathway is also upregulated in injured renal tubular epithelia, both in acute kidney injury and chronic kidney disease. The renal tubular epithelium is an important target of kidney injury, and its response (repair versus persistent injury) is critical for determining whether tubulointerstitial fibrosis, the hallmark of chronic kidney disease, develops. This review discusses how Wnt/?-catenin signaling in the injured tubular epithelia promotes either repair or fibrosis after kidney injury. There is data suggesting that epithelial Wnt/?-catenin signaling is beneficial in acute kidney injury and important in tubular progenitors responsible for epithelial repair. The role of Wnt/?-catenin signaling in chronically injured epithelia is less clear. There is convincing data that Wnt/?-catenin signaling in interstitial fibroblasts and pericytes contributes to the extracellular matrix accumulation that defines fibrosis. However, some recent studies question whether Wnt/?-catenin signaling in chronically injured epithelia actually promotes fibrosis or repair. äRenal Tubule Repair: Is Wnt/?-Catenin a Friend or Foe?(epmc).pdf DeepDyve Pubget Overpricing