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10.1093/cvr/cvx148 http://scihub22266oqcxt.onion/10.1093/cvr/cvx148 C5852547!5852547!28957540     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cardiovasc+Res 2017 ; 113 (12): 1465-73 Nephropedia Template TP {{tp|p=28957540|t=2017. Treatment strategies for the right heart in pulmonary hypertension |pdf=|usr=}}{{28957540}} gab.com Text Treatment strategies for the right heart in pulmonary hypertension JO: Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=28957540 #FOAvip The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wall stress since this is the main determinant of changes to the ventricle. Secondly, we discuss treatment strategies targeting the detrimental consequences of increased RV wall stress. To reduce wall stress, afterload reduction is the essential. Additionally, preload to the ventricle can be reduced by diuretics, by atrial septostomy, and potentially by mechanical ventricular support. Secondary to ventricular wall stress, left-to-right asynchrony, altered myocardial energy metabolism, and neurohumoral activation will occur. These may be targeted by optimising RV contraction with pacing, by iron supplement, by angiogenesis and improving mitochondrial function, and by neurohumoral modulation, respectively. We conclude that several treatment strategies for the right heart are available; however, evidence is still limited and further research is needed before clinical application can be recommended. Twit Text FOAVip Treatment strategies for the right heart in pulmonary hypertension ????Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=28957540 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28957540 #FOAvip English Wikipedia <ref>{{Cite pmid|28957540}}</ref> Treatment strategies for the right heart in pulmonary hypertension #MMPMID28957540 Westerhof BE; Saouti N; van der Laarse WJ; Westerhof N; Vonk Noordegraaf A Cardiovasc Res 2017[Oct]; 113 (12): 1465-73 PMID28957540show ga The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wall stress since this is the main determinant of changes to the ventricle. Secondly, we discuss treatment strategies targeting the detrimental consequences of increased RV wall stress. To reduce wall stress, afterload reduction is the essential. Additionally, preload to the ventricle can be reduced by diuretics, by atrial septostomy, and potentially by mechanical ventricular support. Secondary to ventricular wall stress, left-to-right asynchrony, altered myocardial energy metabolism, and neurohumoral activation will occur. These may be targeted by optimising RV contraction with pacing, by iron supplement, by angiogenesis and improving mitochondrial function, and by neurohumoral modulation, respectively. We conclude that several treatment strategies for the right heart are available; however, evidence is still limited and further research is needed before clinical application can be recommended. äTreatment strategies for the right heart in pulmonary hypertension (epmc).pdf DeepDyve Pubget Overpricing