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10.1021/jm4018042 http://scihub22266oqcxt.onion/10.1021/jm4018042 C5852381!5852381!24978112     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Chem 2014 ; 57 (15): 6342-53 Nephropedia Template TP {{tp|p=24978112|t=2014. Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein?Tyrosine Phosphatase PTPN6 |pdf=|usr=}}{{24978112}} gab.com Text Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein Tyrosine Phosphatase PTPN6 JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=24978112 #FOAvip The aberrant activation of STAT3 occurs in many human cancers and promotes tumor progression. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3. Synthesized carbazole derived with fluorophore compound 12 was discovered to target STAT3 phosphorylation. Compound 12 was found to inhibit STAT3-mediated transcription as well as to reduce IL-6 induced STAT3 phosphorylation in cancer cell lines expressing both elevated and low levels of phospho-STAT3 (Y705). Compound 12 potently induced apoptosis in a broad number of TNBC cancer cell lines in vitro and was effective at inhibiting the in vivo growth of human TNBC xenograft tumors (SUM149) without any observed toxicity. Compound 12 also effectively inhibited the growth of human lung tumor xenografts (A549) harboring aberrantly active STAT3. In vitro and in vivo studies showed that the inhibitory effects of 12 on phospho-STAT3 were through up-regulation of the protein?tyrosine phosphatase PTPN6. Our present studies strongly support the continued preclinical evaluation of compound 12 as a potential chemotherapeutic agent for TNBC and cancers with constitutive STAT3 signaling. Twit Text FOAVip Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein Tyrosine Phosphatase PTPN6 ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=24978112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24978112 #FOAvip English Wikipedia <ref>{{Cite pmid|24978112}}</ref> Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein?Tyrosine Phosphatase PTPN6 #MMPMID24978112 Hou S; Yi YW; Jin Kang H; Zhang L; Kim HJ; Kong Y; Liu Y; Wang K; Kong HS; Grindrod S; Bae I; Brown ML J Med Chem 2014[Aug]; 57 (15): 6342-53 PMID24978112show ga The aberrant activation of STAT3 occurs in many human cancers and promotes tumor progression. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3. Synthesized carbazole derived with fluorophore compound 12 was discovered to target STAT3 phosphorylation. Compound 12 was found to inhibit STAT3-mediated transcription as well as to reduce IL-6 induced STAT3 phosphorylation in cancer cell lines expressing both elevated and low levels of phospho-STAT3 (Y705). Compound 12 potently induced apoptosis in a broad number of TNBC cancer cell lines in vitro and was effective at inhibiting the in vivo growth of human TNBC xenograft tumors (SUM149) without any observed toxicity. Compound 12 also effectively inhibited the growth of human lung tumor xenografts (A549) harboring aberrantly active STAT3. In vitro and in vivo studies showed that the inhibitory effects of 12 on phospho-STAT3 were through up-regulation of the protein?tyrosine phosphatase PTPN6. Our present studies strongly support the continued preclinical evaluation of compound 12 as a potential chemotherapeutic agent for TNBC and cancers with constitutive STAT3 signaling. äNovel Carbazole Inhibits Phospho-STAT3 through Induction of Protein?Ty(epmc).pdf DeepDyve Pubget Overpricing