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10.1016/j.omtm.2018.01.010 http://scihub22266oqcxt.onion/10.1016/j.omtm.2018.01.010 C5852291!5852291!29552577     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29552577&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Mol+Ther+Methods+Clin+Dev 2018 ; 8 (ä): 210-21 Nephropedia Template TP {{tp|p=29552577|t=2018. The Pharmacology of T Cell Therapies |pdf=|usr=}}{{29552577}} gab.com Text The Pharmacology of T Cell Therapies JO: Mol Ther Methods Clin Dev http://www.kidney.de/pget.php?&tw=1&pmid=29552577 #FOAvip Adoptive cellular therapy using T cells with tumor specificity derived from either natural T cell receptors (TCRs) or an artificial chimeric antigen receptor (CAR) has reached late phase clinical testing, with two CAR T cell therapies achieving regulatory approval within the United States in 2017. The effective use of these therapies depends upon an understanding of their pharmacology, which is quite divergent from traditional small molecule or biologic drugs. We review the different types of T cell therapy under clinical development, the factors affecting cellular kinetics following infusion, and the relationship between these cellular kinetics and anti-cancer activity. We also discuss the toxicity associated with T cell therapies, with an emphasis on cytokine release syndrome and neurotoxicity, and the gaps in knowledge regarding these frequent and unique adverse effects. Twit Text FOAVip The Pharmacology of T Cell Therapies ????Mol Ther Methods Clin Dev http://www.kidney.de/pget.php?&tw=1&pmid=29552577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29552577 #FOAvip English Wikipedia <ref>{{Cite pmid|29552577}}</ref> The Pharmacology of T Cell Therapies #MMPMID29552577 Milone MC; Bhoj VG Mol Ther Methods Clin Dev 2018[Mar]; 8 (ä): 210-21 PMID29552577show ga Adoptive cellular therapy using T cells with tumor specificity derived from either natural T cell receptors (TCRs) or an artificial chimeric antigen receptor (CAR) has reached late phase clinical testing, with two CAR T cell therapies achieving regulatory approval within the United States in 2017. The effective use of these therapies depends upon an understanding of their pharmacology, which is quite divergent from traditional small molecule or biologic drugs. We review the different types of T cell therapy under clinical development, the factors affecting cellular kinetics following infusion, and the relationship between these cellular kinetics and anti-cancer activity. We also discuss the toxicity associated with T cell therapies, with an emphasis on cytokine release syndrome and neurotoxicity, and the gaps in knowledge regarding these frequent and unique adverse effects. äThe Pharmacology of T Cell Therapies (epmc).pdf DeepDyve Pubget Overpricing