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10.1038/s41419-018-0445-9 http://scihub22266oqcxt.onion/10.1038/s41419-018-0445-9 C5852148!5852148 !29540670     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29540670 &cmd=llinks): Failed to open stream: HTTP request failed! 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Decreased autophagy induced by ?(1)-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis |pdf=|usr=}}{{29540670 }} gab.com Text Decreased autophagy induced by (1)-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29540670 #FOAvip It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-?(1)-adrenergic receptor autoantibodies (?(1)-AABs) decreased myocardial autophagy, but the role of decreased autophagy in cardiomyocyte apoptosis remains unclear. In the present study, we used a ?(1)-AAB-immunized rat model to investigate the role of decreased autophagy in cardiomyocyte apoptosis. We reported that the level of autophagic flux increased early and then decreased in an actively ?(1)-AAB-immunized rat model. Rapamycin, an mTOR inhibitor, restored myocardial apoptosis in the presence of ?(1)-AABs. Further, we found that the early increase of autophagy was an adaptive stress response that is possibly unrelated to ?(1)-AR, and the activation of the ?(1)-AR and PKA contributed to late decreased autophagy. Then, after upregulating or inhibiting autophagy with rapamycin, Atg5 overexpression adenovirus or 3-methyladenine in cultured primary neonatal rat cardiomyocytes, we found that autophagy decline promoted myocardial apoptosis effectively through the mitochondrial apoptotic pathway. In conclusion, the reduction of apoptosis through the proper regulation of autophagy may be important for treating patients with ?(1)-AAB-positive heart dysfunction. Twit Text FOAVip Decreased autophagy induced by (1)-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29540670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29540670 #FOAvip English Wikipedia <ref>{{Cite pmid|29540670 }}</ref> Decreased autophagy induced by ?(1)-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis #MMPMID29540670 Wang L ; Li Y ; Ning N ; Wang J ; Yan Z ; Zhang S ; Jiao X ; Wang X ; Liu H Cell Death Dis 2018[Mar]; 9 (3 ): 406 PMID29540670 show ga It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-?(1)-adrenergic receptor autoantibodies (?(1)-AABs) decreased myocardial autophagy, but the role of decreased autophagy in cardiomyocyte apoptosis remains unclear. In the present study, we used a ?(1)-AAB-immunized rat model to investigate the role of decreased autophagy in cardiomyocyte apoptosis. We reported that the level of autophagic flux increased early and then decreased in an actively ?(1)-AAB-immunized rat model. Rapamycin, an mTOR inhibitor, restored myocardial apoptosis in the presence of ?(1)-AABs. Further, we found that the early increase of autophagy was an adaptive stress response that is possibly unrelated to ?(1)-AR, and the activation of the ?(1)-AR and PKA contributed to late decreased autophagy. Then, after upregulating or inhibiting autophagy with rapamycin, Atg5 overexpression adenovirus or 3-methyladenine in cultured primary neonatal rat cardiomyocytes, we found that autophagy decline promoted myocardial apoptosis effectively through the mitochondrial apoptotic pathway. In conclusion, the reduction of apoptosis through the proper regulation of autophagy may be important for treating patients with ?(1)-AAB-positive heart dysfunction. |Animals [MESH] |Apoptosis/*drug effects [MESH] |Autoantibodies/*pharmacology [MESH] |Autophagy/*drug effects [MESH] |Male [MESH] |Myocytes, Cardiac/*cytology/drug effects/metabolism [MESH] |Rats [MESH] |Rats, Wistar [MESH]Decreased autophagy induced by ?(1)-adrenoceptor autoantibodies contri(epmc).pdf DeepDyve Pubget Overpricing