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10.1038/s41467-018-03507-2 http://scihub22266oqcxt.onion/10.1038/s41467-018-03507-2 C5852131!5852131!29540683     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29540683|t=2018. The choroid plexus is an important circadian clock component |pdf=|usr=}}{{29540683}} gab.com Text The choroid plexus is an important circadian clock component JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29540683 #FOAvip Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN clocks to this hierarchy remains unclear. We examine circadian oscillations of clock gene expression in various brain loci and discovered that in mouse, robust, higher amplitude, relatively faster oscillations occur in the choroid plexus (CP) compared to the SCN. Our computational analysis and modeling show that the CP achieves these properties by synchronization of ?twist? circadian oscillators via gap-junctional connections. Using an in vitro tissue coculture model and in vivo targeted deletion of the Bmal1 gene to silence the CP circadian clock, we demonstrate that the CP clock adjusts the SCN clock likely via circulation of cerebrospinal fluid, thus finely tuning behavioral circadian rhythms. Twit Text FOAVip The choroid plexus is an important circadian clock component ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29540683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29540683 #FOAvip English Wikipedia <ref>{{Cite pmid|29540683}}</ref> The choroid plexus is an important circadian clock component #MMPMID29540683 Myung J; Schmal C; Hong S; Tsukizawa Y; Rose P; Zhang Y; Holtzman MJ; De Schutter E; Herzel H; Bordyugov G; Takumi T Nat Commun 2018[]; 9 (ä): ä PMID29540683show ga Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN clocks to this hierarchy remains unclear. We examine circadian oscillations of clock gene expression in various brain loci and discovered that in mouse, robust, higher amplitude, relatively faster oscillations occur in the choroid plexus (CP) compared to the SCN. Our computational analysis and modeling show that the CP achieves these properties by synchronization of ?twist? circadian oscillators via gap-junctional connections. Using an in vitro tissue coculture model and in vivo targeted deletion of the Bmal1 gene to silence the CP circadian clock, we demonstrate that the CP clock adjusts the SCN clock likely via circulation of cerebrospinal fluid, thus finely tuning behavioral circadian rhythms. äThe choroid plexus is an important circadian clock component (epmc).pdf DeepDyve Pubget Overpricing