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10.1038/s41598-018-22749-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-22749-0 C5852083!5852083!29540740     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29540740|t=2018. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies |pdf=|usr=}}{{29540740}} gab.com Text Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29540740 #FOAvip Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-system microfluidic platforms that are compatible with the quantitative study of a range of compounds, including lipophilic drugs. We describe three different platform designs ? ?4-way?, ?7-way?, and ?10-way? ? each accommodating a mixing chamber and up to 4, 7, or 10 MPSs. Platforms accommodate multiple different MPS flow configurations, each with internal re-circulation to enhance molecular exchange, and feature on-board pneumatically-driven pumps with independently programmable flow rates to provide precise control over both intra- and inter-MPS flow partitioning and drug distribution. We first developed a 4-MPS system, showing accurate prediction of secreted liver protein distribution and 2-week maintenance of phenotypic markers. We then developed 7-MPS and 10-MPS platforms, demonstrating reliable, robust operation and maintenance of MPS phenotypic function for 3 weeks (7-way) and 4 weeks (10-way) of continuous interaction, as well as PK analysis of diclofenac metabolism. This study illustrates several generalizable design and operational principles for implementing multi-MPS ?physiome-on-a-chip? approaches in drug discovery. Twit Text FOAVip Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29540740 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29540740 #FOAvip English Wikipedia <ref>{{Cite pmid|29540740}}</ref> Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies #MMPMID29540740 Edington CD; Chen WLK; Geishecker E; Kassis T; Soenksen LR; Bhushan BM; Freake D; Kirschner J; Maass C; Tsamandouras N; Valdez J; Cook CD; Parent T; Snyder S; Yu J; Suter E; Shockley M; Velazquez J; Velazquez JJ; Stockdale L; Papps JP; Lee I; Vann N; Gamboa M; LaBarge ME; Zhong Z; Wang X; Boyer LA; Lauffenburger DA; Carrier RL; Communal C; Tannenbaum SR; Stokes CL; Hughes DJ; Rohatgi G; Trumper DL; Cirit M; Griffith LG Sci Rep 2018[]; 8 (ä): ä PMID29540740show ga Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-system microfluidic platforms that are compatible with the quantitative study of a range of compounds, including lipophilic drugs. We describe three different platform designs ? ?4-way?, ?7-way?, and ?10-way? ? each accommodating a mixing chamber and up to 4, 7, or 10 MPSs. Platforms accommodate multiple different MPS flow configurations, each with internal re-circulation to enhance molecular exchange, and feature on-board pneumatically-driven pumps with independently programmable flow rates to provide precise control over both intra- and inter-MPS flow partitioning and drug distribution. We first developed a 4-MPS system, showing accurate prediction of secreted liver protein distribution and 2-week maintenance of phenotypic markers. We then developed 7-MPS and 10-MPS platforms, demonstrating reliable, robust operation and maintenance of MPS phenotypic function for 3 weeks (7-way) and 4 weeks (10-way) of continuous interaction, as well as PK analysis of diclofenac metabolism. This study illustrates several generalizable design and operational principles for implementing multi-MPS ?physiome-on-a-chip? approaches in drug discovery. äInterconnected Microphysiological Systems for Quantitative Biology and(epmc).pdf DeepDyve Pubget Overpricing