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10.1016/j.synbio.2017.10.004 http://scihub22266oqcxt.onion/10.1016/j.synbio.2017.10.004 C5851904!5851904!29552649     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Synth+Syst+Biotechnol 2017 ; 2 (4): 253-8 Nephropedia Template TP {{tp|p=29552649|t=2017. Experimental evolution and proximate mechanisms in biology |pdf=|usr=}}{{29552649}} gab.com Text Experimental evolution and proximate mechanisms in biology JO: Synth Syst Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=29552649 #FOAvip Biological functions ? studied by molecular, systems and behavioral biology ? are referred to as proximate mechanisms. Why and how they have emerged from the course of evolution are referred to as ultimate mechanisms. Despite the conceptual and technical schism between the disciplines that focus on each, studies from one side can benefit the other. Experimental evolution is an emerging field at the crossroads of functional and evolutionary biology. Herein microorganisms and mammalian cell lines evolve in well-controlled laboratory environments over multiple generations. Phenotypic changes arising from the process are then characterized in genetics and function to understand the evolutionary process. While providing empirical tests to evolutionary questions, such studies also offer opportunities of new insights into proximate mechanisms. Experimental evolution optimizes biological systems by means of adaptation; the adapted systems with their mutations present unique perturbed states of the systems that generate new and often unexpected output/performance. Hence, learning about these states not only adds to but also might deepen knowledge on the proximate processes. To demonstrate this point, five examples in experimental evolution are introduced, and their relevance to functional biology explicated. In some examples, from evolution experiments, updates were made to known proximate processes ? gene regulation and cell polarization. In some examples, new contexts were found for known proximate processes ? cell division and drug resistance of cancer. In one example, a new cellular mechanism was discovered. These cases identify ways the approach of experimental evolution can be used to ask questions in functional biology. Twit Text FOAVip Experimental evolution and proximate mechanisms in biology ????Synth Syst Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=29552649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29552649 #FOAvip English Wikipedia <ref>{{Cite pmid|29552649}}</ref> Experimental evolution and proximate mechanisms in biology #MMPMID29552649 Yi X Synth Syst Biotechnol 2017[Dec]; 2 (4): 253-8 PMID29552649show ga Biological functions ? studied by molecular, systems and behavioral biology ? are referred to as proximate mechanisms. Why and how they have emerged from the course of evolution are referred to as ultimate mechanisms. Despite the conceptual and technical schism between the disciplines that focus on each, studies from one side can benefit the other. Experimental evolution is an emerging field at the crossroads of functional and evolutionary biology. Herein microorganisms and mammalian cell lines evolve in well-controlled laboratory environments over multiple generations. Phenotypic changes arising from the process are then characterized in genetics and function to understand the evolutionary process. While providing empirical tests to evolutionary questions, such studies also offer opportunities of new insights into proximate mechanisms. Experimental evolution optimizes biological systems by means of adaptation; the adapted systems with their mutations present unique perturbed states of the systems that generate new and often unexpected output/performance. Hence, learning about these states not only adds to but also might deepen knowledge on the proximate processes. To demonstrate this point, five examples in experimental evolution are introduced, and their relevance to functional biology explicated. In some examples, from evolution experiments, updates were made to known proximate processes ? gene regulation and cell polarization. In some examples, new contexts were found for known proximate processes ? cell division and drug resistance of cancer. In one example, a new cellular mechanism was discovered. These cases identify ways the approach of experimental evolution can be used to ask questions in functional biology. äExperimental evolution and proximate mechanisms in biology (epmc).pdf DeepDyve Pubget Overpricing