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10.1016/j.sjbs.2017.11.028

http://scihub22266oqcxt.onion/10.1016/j.sjbs.2017.11.028
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C5851900!5851900!29551936
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suck abstract from ncbi


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pmid29551936      Saudi+J+Biol+Sci 2017 ; 24 (8): 1859-65
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  • Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro #MMPMID29551936
  • He J
  • Saudi J Biol Sci 2017[Dec]; 24 (8): 1859-65 PMID29551936show ga
  • Non-small cell lung cancer (NSCLC) is a major type of lung cancer, with the highest mortality rate in all cancers. For all stages of NSCLC, the five-year survival is less than fifteen percent. Epithelial-mesenchymal transition (EMT) is a significant process in tumor occurrence and development, in which microRNAs may play an important role. In many cancers, microRNA-15's family member can act as suppressors or oncogenes of tumors; however, the relation between these microRNAs and EMT in lung cancer remains unclear. According to our study, miR-15a expression decreased in tumor tissues compared with than that in adjacent tissue samples. Knocking down miR-15a expression in NSCLC cells inhibited apoptosis and facilitated cell proliferation and invasion, and. Moreover, down-regulating miR-15a decreased the expression of an EMT-associated protein, E-cadherin, while increased those of vimentin, N-cadherin, and slug.
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