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10.7554/eLife.32723 http://scihub22266oqcxt.onion/10.7554/eLife.32723 C5851698!5851698 !29513218     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29513218 &cmd=llinks): Failed to open stream: HTTP request failed! 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TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes |pdf=|usr=}}{{29513218 }} gab.com Text TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=29513218 #FOAvip Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky cargo collagen? TANGO1 is known to form a ring that corrals COPII coats, and we show here how this ring or fence is assembled. Our data reveal that a TANGO1 ring is organized by its radial interaction with COPII, and lateral interactions with cTAGE5, TANGO1-short or itself. Of particular interest is the finding that TANGO1 recruits ERGIC membranes for collagen export via the NRZ (NBAS/RINT1/ZW10) tether complex. Therefore, TANGO1 couples retrograde membrane flow to anterograde cargo transport. Without the NRZ complex, the TANGO1 ring does not assemble, suggesting its role in nucleating or stabilising this process. Thus, coordinated capture of COPII coats, cTAGE5, TANGO1-short, and tethers by TANGO1 assembles a collagen export machine at the ER. Twit Text FOAVip TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=29513218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29513218 #FOAvip English Wikipedia <ref>{{Cite pmid|29513218 }}</ref> TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes #MMPMID29513218 Raote I ; Ortega-Bellido M ; Santos AJ ; Foresti O ; Zhang C ; Garcia-Parajo MF ; Campelo F ; Malhotra V Elife 2018[Mar]; 7 (ä): ä PMID29513218 show ga Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky cargo collagen? TANGO1 is known to form a ring that corrals COPII coats, and we show here how this ring or fence is assembled. Our data reveal that a TANGO1 ring is organized by its radial interaction with COPII, and lateral interactions with cTAGE5, TANGO1-short or itself. Of particular interest is the finding that TANGO1 recruits ERGIC membranes for collagen export via the NRZ (NBAS/RINT1/ZW10) tether complex. Therefore, TANGO1 couples retrograde membrane flow to anterograde cargo transport. Without the NRZ complex, the TANGO1 ring does not assemble, suggesting its role in nucleating or stabilising this process. Thus, coordinated capture of COPII coats, cTAGE5, TANGO1-short, and tethers by TANGO1 assembles a collagen export machine at the ER. |Antigens, Neoplasm/chemistry/*genetics [MESH] |Aryl Hydrocarbon Receptor Nuclear Translocator/chemistry/*genetics [MESH] |COP-Coated Vesicles/chemistry/genetics [MESH] |Cell Cycle Proteins/chemistry/genetics [MESH] |Chromosomal Proteins, Non-Histone/chemistry/genetics [MESH] |Collagen/chemistry/genetics/metabolism [MESH] |Endoplasmic Reticulum/chemistry/*genetics [MESH] |Golgi Apparatus/chemistry/genetics [MESH] |HeLa Cells [MESH] |Humans [MESH] |Microtubule-Associated Proteins/chemistry/genetics [MESH] |Neoplasm Proteins/chemistry/*genetics [MESH]TANGO1 builds a machine for collagen export by recruiting and spatiall(epmc).pdf DeepDyve Pubget Overpricing