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10.1177/1533033818762680 http://scihub22266oqcxt.onion/10.1177/1533033818762680 C5851100!5851100!29528777     free     free     free       Technol+Cancer+Res+Treat 2018 ; 17 (ä): ä Nephropedia Template TP {{tp|p=29528777|t=2018. ING5 is a Potential Target for Osteosarcoma Therapy |pdf=|usr=}}{{29528777}} gab.com Text ING5 is a Potential Target for Osteosarcoma Therapy JO: Technol Cancer Res Treat http://www.kidney.de/pget.php?&tw=1&pmid=29528777 #FOAvip Osteosarcoma is one of the most common primary malignant bone tumors. The inhibitor of growth family of protein 5 has been identified as a tumor suppressor in many cancers. In this study, we confirmed the downregulation of the both inhibitor of growth family of protein 5 and messenger RNA levels in cancer tissues using Western blot and real-time polymerase chain reaction. In order to find the antitumor roles of inhibitor of growth family of protein 5, osteosarcoma cells, HOS, and MG63 were transfected with the plasmid pCDNA-3.1-inhibitor of growth family of protein 5. Overexpression of Inhibitor of growth family of protein 5 could induce apoptosis and inhibit cell proliferation in osteosarcoma cells. Furthermore, Western blot analysis showed that p-Smad2, p-Smad3, and Smad4 were increased in inhibitor of growth family of protein 5-expressing osteosarcoma cells. Our results indicated that overexpression of inhibitor of growth family of protein 5 in osteosarcoma cells induces apoptosis by activating the Smad pathway, thus proposing a promising role for inhibitor of growth family of protein 5 in treatment of patients with osteosarcoma. Twit Text FOAVip ING5 is a Potential Target for Osteosarcoma Therapy ????Technol Cancer Res Treat http://www.kidney.de/pget.php?&tw=1&pmid=29528777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29528777 #FOAvip English Wikipedia <ref>{{Cite pmid|29528777}}</ref> ING5 is a Potential Target for Osteosarcoma Therapy #MMPMID29528777 Zhang X; Xu ZH; Xie H; Sun YW; Liu J; Zhao YB Technol Cancer Res Treat 2018[]; 17 (ä): ä PMID29528777show ga Osteosarcoma is one of the most common primary malignant bone tumors. The inhibitor of growth family of protein 5 has been identified as a tumor suppressor in many cancers. In this study, we confirmed the downregulation of the both inhibitor of growth family of protein 5 and messenger RNA levels in cancer tissues using Western blot and real-time polymerase chain reaction. In order to find the antitumor roles of inhibitor of growth family of protein 5, osteosarcoma cells, HOS, and MG63 were transfected with the plasmid pCDNA-3.1-inhibitor of growth family of protein 5. Overexpression of Inhibitor of growth family of protein 5 could induce apoptosis and inhibit cell proliferation in osteosarcoma cells. Furthermore, Western blot analysis showed that p-Smad2, p-Smad3, and Smad4 were increased in inhibitor of growth family of protein 5-expressing osteosarcoma cells. Our results indicated that overexpression of inhibitor of growth family of protein 5 in osteosarcoma cells induces apoptosis by activating the Smad pathway, thus proposing a promising role for inhibitor of growth family of protein 5 in treatment of patients with osteosarcoma. äING5 is a Potential Target for Osteosarcoma Therapy (epmc).pdf DeepDyve Pubget Overpricing