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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mem+Inst+Oswaldo+Cruz 2018 ; 113 (4): ä Nephropedia Template TP
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Correlation of transforming growth factor-?1 and tumour necrosis factor levels with left ventricular function in Chagas disease #MMPMID29513876
Mem Inst Oswaldo Cruz 2018[]; 113 (4): ä PMID29513876show ga
BACKGROUND: Transforming growth factor ?1 (TGF-?1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function. OBJECTIVES: We determined whether TGF-?1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease. METHODS: This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-?1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function. FINDINGS: TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-?1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction. CONCLUSIONS: TNF is increased, while TGF-?1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-?1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.