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10.1093/molbev/msx174 http://scihub22266oqcxt.onion/10.1093/molbev/msx174 C5850603!5850603!28595344     free     free     free       Mol+Biol+Evol 2017 ; 34 (9): 2367-79 Nephropedia Template TP {{tp|p=28595344|t=2017. Metabolism and the Evolution of Social Behavior |pdf=|usr=}}{{28595344}} gab.com Text Metabolism and the Evolution of Social Behavior JO: Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=28595344 #FOAvip How does metabolism influence social behavior? This fundamental question at the interface of molecular biology and social evolution is hard to address with experiments in animals, and therefore, we turned to a simple microbial system: swarming in the bacterium Pseudomonas aeruginosa. Using genetic engineering, we excised a locus encoding a key metabolic regulator and disrupted P. aeruginosa?s metabolic prudence, the regulatory mechanism that controls expression of swarming public goods and protects this social behavior from exploitation by cheaters. Then, using experimental evolution, we followed the joint evolution of the genome, the metabolome and the social behavior as swarming re-evolved. New variants emerged spontaneously with mutations that reorganized the metabolome and compensated in distinct ways for the disrupted metabolic prudence. These experiments with a unicellular organism provide a detailed view of how metabolism?currency of all physiological processes?can determine the costs and benefits of a social behavior and ultimately influence how an organism behaves towards other organisms of the same species. Twit Text FOAVip Metabolism and the Evolution of Social Behavior ????Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=28595344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28595344 #FOAvip English Wikipedia <ref>{{Cite pmid|28595344}}</ref> Metabolism and the Evolution of Social Behavior #MMPMID28595344 Boyle KE; Monaco HT; Deforet M; Yan J; Wang Z; Rhee K; Xavier JB Mol Biol Evol 2017[Sep]; 34 (9): 2367-79 PMID28595344show ga How does metabolism influence social behavior? This fundamental question at the interface of molecular biology and social evolution is hard to address with experiments in animals, and therefore, we turned to a simple microbial system: swarming in the bacterium Pseudomonas aeruginosa. Using genetic engineering, we excised a locus encoding a key metabolic regulator and disrupted P. aeruginosa?s metabolic prudence, the regulatory mechanism that controls expression of swarming public goods and protects this social behavior from exploitation by cheaters. Then, using experimental evolution, we followed the joint evolution of the genome, the metabolome and the social behavior as swarming re-evolved. New variants emerged spontaneously with mutations that reorganized the metabolome and compensated in distinct ways for the disrupted metabolic prudence. These experiments with a unicellular organism provide a detailed view of how metabolism?currency of all physiological processes?can determine the costs and benefits of a social behavior and ultimately influence how an organism behaves towards other organisms of the same species. äMetabolism and the Evolution of Social Behavior (epmc).pdf DeepDyve Pubget Overpricing