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10.1007/s00294-017-0754-z

http://scihub22266oqcxt.onion/10.1007/s00294-017-0754-z
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C5849531!5849531!28983660
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suck abstract from ncbi


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pmid28983660      Curr+Genet 2018 ; 64 (2): 327-33
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  • Synthetic Genome Recoding: New genetic codes for new features #MMPMID28983660
  • Kuo J; Stirling F; Lau YH; Shulgina Y; Way JC; Silver PA
  • Curr Genet 2018[Apr]; 64 (2): 327-33 PMID28983660show ga
  • Full genome recoding, or rewriting codon meaning, through chemical synthesis of entire bacterial chromosomes has become feasible in the past several years. Recoding an organism can impart new properties including non-natural amino acid incorporation, virus resistance, and biocontainment. The estimated cost of construction that includes DNA synthesis, assembly by recombination, and troubleshooting, is now comparable to costs of early stage development of drugs or other high-tech products. Here we discuss several recently published assembly methods and provide some thoughts on the future, including how synthetic efforts might benefit from analysis of natural recoding processes and organisms that use alternative genetic codes.
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