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Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Oncotarget 2018 ; 9 (16): 12705-17 Nephropedia Template TP
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Ang-2 promotes lung cancer metastasis by increasing epithelial-mesenchymal transition #MMPMID29560103
Dong Z; Chen J; Yang X; Zheng W; Wang L; Fang M; Wu M; Yao M; Yao D
Oncotarget 2018[Feb]; 9 (16): 12705-17 PMID29560103show ga
Lung cancer is the most common malignant tumor with increasing angiopoietin-2 (Ang-2) and a high rate of metastasis. However, the mechanism of Ang-2 enhancing tumor proliferation and facilitating metastasis remains to be clarified. In this study, Ang-2 expression and its gene transcription on effects of biological behaviors and epithelial-mesenchymal transition (EMT) were investigated in lung cancers. Total incidence of Ang-2 expression in the cancerous tissues was up to 91.8 % (112 of 122) with significantly higher (?2=103.753, P2=7.883, P=0.005), differentiation degree (?2=4.554, P=0.033), tumor node metastasis (TNM) staging (?2=5.039, P=0.025), and 5-year survival rate (?2 =11.220, P2=18.881, P2=0.81, P=0.776) or III & IV (?2=1.845, P=0.174). Over-expression of Ang-2 or Ang-2 mRNA in lung A549 and NCI-H1975 cells were identified among different cell lines. When silencing Ang-2 in A549 cells with specific shRNA-1 transfection, the cell proliferation was significantly inhibited in a time-dependent manner, with up-regulating E-cadherin, down-regulating Vimentin, Twist, and Snail expression, and decreasing invasion and metastasis of cancer cell abilities, suggesting that Ang-2 promote tumor metastasis through increasing EMT, and it could be a potential target for lung cancer therapy.
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Oncotarget 2018 ; 9 (16): 12705-17
