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10.1056/NEJMoa1715474 http://scihub22266oqcxt.onion/10.1056/NEJMoa1715474 C5849140!5849140!29694816     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       N+Engl+J+Med ä ; 378 (17): 1583-92 Nephropedia Template TP {{tp|p=29694816|t=ä. Mass azithromycin distribution for reducing childhood mortality in sub-Saharan Africa |pdf=|usr=}}{{29694816}} gab.com Text Mass azithromycin distribution for reducing childhood mortality in sub-Saharan Africa JO: N Engl J Med http://www.kidney.de/pget.php?&tw=1&pmid=29694816 #FOAvip Background.Interventions to reduce under-5 mortality can either target the vulnerable or include all children regardless of state of health. Here, we assess whether mass distribution of a broad-spectrum antibiotic to pre-school children reduces mortality in sub-Saharan Africa. Methods.MORDOR was a large simple trial that randomized communities in Malawi, Niger, and Tanzania to 4 biannual mass distributions of either oral azithromycin or placebo. Children aged 1-59 months were enumerated and offered treatment. Vital status was assessed at the subsequent biannual census. The primary outcome was aggregate all-cause mortality, with country-specific rates as pre-specified subgroup analyses. Results.In total, 1533 communities were randomized, 190,238 children censused at baseline, and 323,302 person-years monitored. Mean antibiotic coverage over the 4 biannual distributions was 90.4% (SD 10.4%) of the censused population. The overall annual mortality rate in placebo- treated communities was 16.5 per 1000 person-years (9.6 per 1000 person-years in Malawi, 27.5 in Niger, and 5.5 in Tanzania). Antibiotic-treated communities had an estimated 13.5% lower mortality overall (95% CI 6.7%?19.8%, P<0.001). Mortality was 5.7% lower in Malawi (CI - 9.7%?18.9%, P=0.45), 18.1% lower in Niger (CI 10.0%?25.5%, P<0.001), and 3.4% lower in Tanzania (CI -21.2%?23.0%, P=0.77). The greatest reduction was observed in 1-5 month-old children (24.9% lower, CI 10.6%?37.0%, P=0.001). Conclusions.Mass azithromycin distribution to post-neonatal, pre-school children may reduce childhood mortality in sub-Saharan Africa, particularly in high mortality areas such as Niger. Any implementation would need to consider selection for antibiotic resistance. Twit Text FOAVip Mass azithromycin distribution for reducing childhood mortality in sub-Saharan Africa ????N Engl J Med http://www.kidney.de/pget.php?&tw=1&pmid=29694816 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29694816 #FOAvip English Wikipedia <ref>{{Cite pmid|29694816}}</ref> Mass azithromycin distribution for reducing childhood mortality in sub-Saharan Africa #MMPMID29694816 Keenan JD; Bailey RL; West SK; Arzika AM; Hart J; Weaver J; Kalua K; Mrango Z; Ray KJ; Cook C; Lebas E; O'Brien KS; Emerson PM; Porco TC; Leitman TM N Engl J Med ä[]; 378 (17): 1583-92 PMID29694816show ga Background.Interventions to reduce under-5 mortality can either target the vulnerable or include all children regardless of state of health. Here, we assess whether mass distribution of a broad-spectrum antibiotic to pre-school children reduces mortality in sub-Saharan Africa. Methods.MORDOR was a large simple trial that randomized communities in Malawi, Niger, and Tanzania to 4 biannual mass distributions of either oral azithromycin or placebo. Children aged 1-59 months were enumerated and offered treatment. Vital status was assessed at the subsequent biannual census. The primary outcome was aggregate all-cause mortality, with country-specific rates as pre-specified subgroup analyses. Results.In total, 1533 communities were randomized, 190,238 children censused at baseline, and 323,302 person-years monitored. Mean antibiotic coverage over the 4 biannual distributions was 90.4% (SD 10.4%) of the censused population. The overall annual mortality rate in placebo- treated communities was 16.5 per 1000 person-years (9.6 per 1000 person-years in Malawi, 27.5 in Niger, and 5.5 in Tanzania). Antibiotic-treated communities had an estimated 13.5% lower mortality overall (95% CI 6.7%?19.8%, P<0.001). Mortality was 5.7% lower in Malawi (CI - 9.7%?18.9%, P=0.45), 18.1% lower in Niger (CI 10.0%?25.5%, P<0.001), and 3.4% lower in Tanzania (CI -21.2%?23.0%, P=0.77). The greatest reduction was observed in 1-5 month-old children (24.9% lower, CI 10.6%?37.0%, P=0.001). Conclusions.Mass azithromycin distribution to post-neonatal, pre-school children may reduce childhood mortality in sub-Saharan Africa, particularly in high mortality areas such as Niger. Any implementation would need to consider selection for antibiotic resistance. äMass azithromycin distribution for reducing childhood mortality in sub(epmc).pdf DeepDyve Pubget Overpricing