A new approach to PCSK9 therapeutics #MMPMID28264867
Wang N; Tall AR
Circ Res 2017[Mar]; 120 (7): 1063-5 PMID28264867show ga
PCSK9 inhibition is an effective therapy to reduce LDL cholesterol (LDL-C) and cardiovascular events. A recent study shows that one or two doses of inclisiran, a long-acting synthetic small-interfering RNA (siRNA) that selectively targets hepatic PCSK9, causes a sustained reduction of plasma LDL-C for up to 6 months. Pending further studies of safety and efficacy, this may represent an important addition to the armamentarium for inhibiting PCSK9.