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10.1161/CIRCRESAHA.117.310610

http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.117.310610
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C5848492!5848492!28264867
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suck abstract from ncbi

pmid28264867      Circ+Res 2017 ; 120 (7): 1063-5
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  • A new approach to PCSK9 therapeutics #MMPMID28264867
  • Wang N; Tall AR
  • Circ Res 2017[Mar]; 120 (7): 1063-5 PMID28264867show ga
  • PCSK9 inhibition is an effective therapy to reduce LDL cholesterol (LDL-C) and cardiovascular events. A recent study shows that one or two doses of inclisiran, a long-acting synthetic small-interfering RNA (siRNA) that selectively targets hepatic PCSK9, causes a sustained reduction of plasma LDL-C for up to 6 months. Pending further studies of safety and efficacy, this may represent an important addition to the armamentarium for inhibiting PCSK9.
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