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10.1159/000484930

http://scihub22266oqcxt.onion/10.1159/000484930
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suck abstract from ncbi


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pmid29131124
      Med+Princ+Pract 2017 ; 26 (6 ): 523-529
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  • Comparison of Helicobacter pylori Eradication Rates of 2-Week Levofloxacin-Containing Triple Therapy, Levofloxacin-Containing Bismuth Quadruple Therapy, and Standard Bismuth Quadruple Therapy as a First-Line Regimen #MMPMID29131124
  • Kahramano?lu Aksoy E ; Pirinçci Sapmaz F ; Gökta? Z ; Uzman M ; Nazl?gül Y
  • Med Princ Pract 2017[]; 26 (6 ): 523-529 PMID29131124 show ga
  • OBJECTIVE: The aim of this study was to compare the efficacy and safety of 2-week levofloxacin-containing triple therapy, levofloxacin-containing bismuth quadruple therapy, and standard bismuth-containing quadruple therapy as a first-line regimen for the eradication of Helicobacter pylori. METHODS: A total of 329 patients with H. pylori infection were randomly divided into 3 groups to receive one of the following regimens: (a) levofloxacin-containing bismuth quadruple therapy, RBAL (rabeprazole 20 mg, b.i.d., bismuth subsalicylate 562 mg, b.i.d., amoxicillin 1 g, b.i.d, levofloxacin 500 mg, once daily), (b) standard bismuth quadruple therapy, RBMT (rabeprazole 20 mg, b.i.d, subsalicylate 562 mg, b.i.d., metronidazole 500 mg, t.i.d, tetracycline 500 mg, q.i.d), or (c) levofloxacin-containing triple therapy, RAL (rabeprazole 20 mg, b.i.d., amoxicillin 1 g, b.i.d, levofloxacin 500 mg, once daily). The primary outcome was the eradication rate in the intention-to-treat (ITT) and per protocol (PP) analysis. RESULTS: The eradication rates of the above 3 groups using ITT analysis were RBAL 83.8%, RBMT 88.3%, and RAL 74.8% compared with 91.2, 92.5, and 79.2%, respectively, using PP analysis. The eradication rate using RBMT was significantly higher than that of RAL (p = 0.029 in ITT analysis and p = 0.017 in PP analysis). Several side effects occurred in 156 patients (54.1%) in the RBAL group, 215 (52.3%) in the RBMT group, and 56 (26.2%) in the RAL group (p > 0.05, RBAL vs. RBMT; p < 0.001, RBMT vs. RAL; p < 0.001, RBAL vs. RAL). CONCLUSION: All bismuth-containing quadruple therapies had acceptable eradication rates, but levofloxacin-containing triple therapy was not as good as quadruple therapies. Hence, quadruple therapies should be considered the preferred first-line therapy for H. pylori infections.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Amoxicillin/therapeutic use [MESH]
  • |Anti-Bacterial Agents/administration & dosage/adverse effects/*therapeutic use [MESH]
  • |Bismuth/administration & dosage/adverse effects/*therapeutic use [MESH]
  • |Drug Administration Schedule [MESH]
  • |Drug Therapy, Combination [MESH]
  • |Female [MESH]
  • |Helicobacter Infections/*drug therapy [MESH]
  • |Humans [MESH]
  • |Levofloxacin/administration & dosage/adverse effects/*therapeutic use [MESH]
  • |Male [MESH]
  • |Metronidazole/therapeutic use [MESH]
  • |Middle Aged [MESH]
  • |Organometallic Compounds/administration & dosage/adverse effects/*therapeutic use [MESH]
  • |Salicylates/administration & dosage/adverse effects/*therapeutic use [MESH]
  • |Tetracycline/therapeutic use [MESH]


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