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2017 ; 26
(6
): 523-529
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English Wikipedia
Comparison of Helicobacter pylori Eradication Rates of 2-Week
Levofloxacin-Containing Triple Therapy, Levofloxacin-Containing Bismuth Quadruple
Therapy, and Standard Bismuth Quadruple Therapy as a First-Line Regimen
#MMPMID29131124
Kahramano?lu Aksoy E
; Pirinçci Sapmaz F
; Gökta? Z
; Uzman M
; Nazl?gül Y
Med Princ Pract
2017[]; 26
(6
): 523-529
PMID29131124
show ga
OBJECTIVE: The aim of this study was to compare the efficacy and safety of 2-week
levofloxacin-containing triple therapy, levofloxacin-containing bismuth quadruple
therapy, and standard bismuth-containing quadruple therapy as a first-line
regimen for the eradication of Helicobacter pylori. METHODS: A total of 329
patients with H. pylori infection were randomly divided into 3 groups to receive
one of the following regimens: (a) levofloxacin-containing bismuth quadruple
therapy, RBAL (rabeprazole 20 mg, b.i.d., bismuth subsalicylate 562 mg, b.i.d.,
amoxicillin 1 g, b.i.d, levofloxacin 500 mg, once daily), (b) standard bismuth
quadruple therapy, RBMT (rabeprazole 20 mg, b.i.d, subsalicylate 562 mg, b.i.d.,
metronidazole 500 mg, t.i.d, tetracycline 500 mg, q.i.d), or (c)
levofloxacin-containing triple therapy, RAL (rabeprazole 20 mg, b.i.d.,
amoxicillin 1 g, b.i.d, levofloxacin 500 mg, once daily). The primary outcome was
the eradication rate in the intention-to-treat (ITT) and per protocol (PP)
analysis. RESULTS: The eradication rates of the above 3 groups using ITT analysis
were RBAL 83.8%, RBMT 88.3%, and RAL 74.8% compared with 91.2, 92.5, and 79.2%,
respectively, using PP analysis. The eradication rate using RBMT was
significantly higher than that of RAL (p = 0.029 in ITT analysis and p = 0.017 in
PP analysis). Several side effects occurred in 156 patients (54.1%) in the RBAL
group, 215 (52.3%) in the RBMT group, and 56 (26.2%) in the RAL group (p > 0.05,
RBAL vs. RBMT; p < 0.001, RBMT vs. RAL; p < 0.001, RBAL vs. RAL). CONCLUSION: All
bismuth-containing quadruple therapies had acceptable eradication rates, but
levofloxacin-containing triple therapy was not as good as quadruple therapies.
Hence, quadruple therapies should be considered the preferred first-line therapy
for H. pylori infections.
|Adolescent
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Amoxicillin/therapeutic use
[MESH]
|Anti-Bacterial Agents/administration & dosage/adverse effects/*therapeutic use
[MESH]
|Bismuth/administration & dosage/adverse effects/*therapeutic use
[MESH]
|Drug Administration Schedule
[MESH]
|Drug Therapy, Combination
[MESH]
|Female
[MESH]
|Helicobacter Infections/*drug therapy
[MESH]
|Humans
[MESH]
|Levofloxacin/administration & dosage/adverse effects/*therapeutic use
[MESH]
|Male
[MESH]
|Metronidazole/therapeutic use
[MESH]
|Middle Aged
[MESH]
|Organometallic Compounds/administration & dosage/adverse effects/*therapeutic use
[MESH]
|Salicylates/administration & dosage/adverse effects/*therapeutic use
[MESH]