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10.21037/jgo.2017.06.09 http://scihub22266oqcxt.onion/10.21037/jgo.2017.06.09 C5848044!5848044!29564184     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gastrointest+Oncol 2018 ; 9 (1): 180-95 Nephropedia Template TP {{tp|p=29564184|t=2018. How does the tumor microenvironment play a role in hepatobiliary tumors?|pdf=|usr=}}{{29564184}} gab.com Text How does the tumor microenvironment play a role in hepatobiliary tumors JO: J Gastrointest Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29564184 #FOAvip The tumor microenvironment (TME) is defined as the structural and dynamic network of cellular and non-cellular interactions between malignant cells and the surrounding non-malignant matrix. Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are two of the most challenging gastrointestinal malignancies. Despite clinical advancements in understanding tumor biology and growth of the chemotherapeutic industry, there have been no corresponding improvements in prognosis and overall survival of HCC and PDAC. Both of these cancers have a very intimate relationship with their surrounding environment; the TME is thought to actively participate in initiating and sustaining these malignancies. Individual TME constituents play a vital role in chemoresistance and recurrence after surgery and have been established as independent prognostic factors. This review article will highlight the diverse structural components, key signaling pathways, and extracellular matrices of HCC and PDAC and discuss their crosstalk with tumor cells to promote growth and metastasis. The article will also summarize the latest laboratory and clinical research based on therapeutic targets identified within the TME of both HCC and PDAC. Twit Text FOAVip How does the tumor microenvironment play a role in hepatobiliary tumors ????J Gastrointest Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29564184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29564184 #FOAvip English Wikipedia <ref>{{Cite pmid|29564184}}</ref> How does the tumor microenvironment play a role in hepatobiliary tumors? #MMPMID29564184 Kamil F; Rowe JH J Gastrointest Oncol 2018[Feb]; 9 (1): 180-95 PMID29564184show ga The tumor microenvironment (TME) is defined as the structural and dynamic network of cellular and non-cellular interactions between malignant cells and the surrounding non-malignant matrix. Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are two of the most challenging gastrointestinal malignancies. Despite clinical advancements in understanding tumor biology and growth of the chemotherapeutic industry, there have been no corresponding improvements in prognosis and overall survival of HCC and PDAC. Both of these cancers have a very intimate relationship with their surrounding environment; the TME is thought to actively participate in initiating and sustaining these malignancies. Individual TME constituents play a vital role in chemoresistance and recurrence after surgery and have been established as independent prognostic factors. This review article will highlight the diverse structural components, key signaling pathways, and extracellular matrices of HCC and PDAC and discuss their crosstalk with tumor cells to promote growth and metastasis. The article will also summarize the latest laboratory and clinical research based on therapeutic targets identified within the TME of both HCC and PDAC. äHow does the tumor microenvironment play a role in hepatobiliary tumor(epmc).pdf DeepDyve Pubget Overpricing