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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Thromb+Haemost 2015 ; 13 (11): 1949-59 Nephropedia Template TP
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Spatio-temporal regulation of coagulation and platelet activation during the hemostatic response in vivo #MMPMID26386264
Ivanciu L; Stalker T
J Thromb Haemost 2015[Nov]; 13 (11): 1949-59 PMID26386264show ga
The hemostatic response requires the tightly regulated interaction of the coagulation system, platelets, other blood cells and components of the vessel wall at a site of vascular injury. The dysregulation of this response may result in excessive bleeding if the response is impaired, and pathologic thrombosis with vessel occlusion and tissue ischemia if the response is overly robust. Extensive studies over the past decade have sought to unravel the regulatory mechanisms that coordinate the multiple biochemical and cellular responses in time and space to ensure that an optimal response to vascular damage is achieved. These studies have relied in part on advances in in vivo imaging techniques in animal models, allowing for the direct visualization of various molecular and cellular events in real time during the hemostatic response. This review summarizes knowledge gained using these in vivo imaging and other approaches that provides new insights into the spatio-temporal regulation of coagulation and platelet activation at a site of vascular injury.