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2015 ; 13
(11
): 1949-59
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Spatiotemporal regulation of coagulation and platelet activation during the
hemostatic response in vivo
#MMPMID26386264
Ivanciu L
; Stalker TJ
J Thromb Haemost
2015[Nov]; 13
(11
): 1949-59
PMID26386264
show ga
The hemostatic response requires the tightly regulated interaction of the
coagulation system, platelets, other blood cells and components of the vessel
wall at a site of vascular injury. The dysregulation of this response may result
in excessive bleeding if the response is impaired, and pathologic thrombosis with
vessel occlusion and tissue ischemia if the response is overly robust. Extensive
studies over the past decade have sought to unravel the regulatory mechanisms
that coordinate the multiple biochemical and cellular responses in time and space
to ensure that an optimal response to vascular damage is achieved. These studies
have relied in part on advances in in vivo imaging techniques in animal models,
allowing for the direct visualization of various molecular and cellular events in
real time during the hemostatic response. This review summarizes knowledge gained
with these in vivo imaging and other approaches that provides new insights into
the spatiotemporal regulation of coagulation and platelet activation at a site of
vascular injury.