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10.1016/j.cell.2018.01.031 http://scihub22266oqcxt.onion/10.1016/j.cell.2018.01.031 C5847171!5847171!29474907     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2018 ; 172 (5): 1063-1078.e19 Nephropedia Template TP {{tp|p=29474907|t=2018. Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis |pdf=|usr=}}{{29474907}} gab.com Text Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=29474907 #FOAvip Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers. Twit Text FOAVip Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=29474907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29474907 #FOAvip English Wikipedia <ref>{{Cite pmid|29474907}}</ref> Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis #MMPMID29474907 Silva CG; Peyre E; Adhikari MH; Tielens S; Tanco S; Van Damme P; Magno L; Krusy N; Agirman G; Magiera MM; Kessaris N; Malgrange B; Andrieux A; Janke C; Nguyen L Cell 2018[Feb]; 172 (5): 1063-1078.e19 PMID29474907show ga Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers. äCell-Intrinsic Control of Interneuron Migration Drives Cortical Morpho(epmc).pdf DeepDyve Pubget Overpricing