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10.1007/s00399-017-0542-y http://scihub22266oqcxt.onion/10.1007/s00399-017-0542-y C5846830!5846830!29214349     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Herzschrittmacherther+Elektrophysiol 2018 ; 29 (1): 30-5 Nephropedia Template TP {{tp|p=29214349|t=2018. Ion channels as part of macromolecular multiprotein complexes: Clinical significance |pdf=|usr=}}{{29214349}} gab.com Text Ion channels as part of macromolecular multiprotein complexes: Clinical significance JO: Herzschrittmacherther Elektrophysiol http://www.kidney.de/pget.php?&tw=1&pmid=29214349 #FOAvip Ion channels and Ca2+-handling proteins involved in the regulation of cardiac electrophysiology and contractility are organized in macromolecular multiprotein complexes. Recent molecular and cellular studies have significantly enhanced our understanding of the composition of these macromolecular complexes and have helped to elucidate their role in the dynamic regulation of ion channel function. Moreover, it has become clear that alterations in the composition of ion channel macromolecular complexes, for example, due to genetic mutations or acquired alterations in the expression of individual components, may lead to ion channel dysfunction and arrhythmogenesis. Here, we review novel insights into the composition of the major ion channel macromolecular complexes and discuss the potential clinical significance of alterations in these dynamic multiprotein structures. Twit Text FOAVip Ion channels as part of macromolecular multiprotein complexes: Clinical significance ????Herzschrittmacherther Elektrophysiol http://www.kidney.de/pget.php?&tw=1&pmid=29214349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29214349 #FOAvip English Wikipedia <ref>{{Cite pmid|29214349}}</ref> Ion channels as part of macromolecular multiprotein complexes: Clinical significance #MMPMID29214349 Heijman J; Dobrev D Herzschrittmacherther Elektrophysiol 2018[]; 29 (1): 30-5 PMID29214349show ga Ion channels and Ca2+-handling proteins involved in the regulation of cardiac electrophysiology and contractility are organized in macromolecular multiprotein complexes. Recent molecular and cellular studies have significantly enhanced our understanding of the composition of these macromolecular complexes and have helped to elucidate their role in the dynamic regulation of ion channel function. Moreover, it has become clear that alterations in the composition of ion channel macromolecular complexes, for example, due to genetic mutations or acquired alterations in the expression of individual components, may lead to ion channel dysfunction and arrhythmogenesis. Here, we review novel insights into the composition of the major ion channel macromolecular complexes and discuss the potential clinical significance of alterations in these dynamic multiprotein structures. äIon channels as part of macromolecular multiprotein complexes: Clinica(epmc).pdf DeepDyve Pubget Overpricing