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10.1371/journal.pone.0193967 http://scihub22266oqcxt.onion/10.1371/journal.pone.0193967 C5846787!5846787!29529056     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2018 ; 13 (3): ä Nephropedia Template TP {{tp|p=29529056|t=2018. Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction |pdf=|usr=}}{{29529056}} gab.com Text Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29529056 #FOAvip Objectives: A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure?a measure of diastolic LV dysfunction?increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium. Methods: We measured echocardiographic diastolic LV function and plasma dp-ucMGP (ELISA) in 668 Flemish and for replication in 386 Swiss. Results: Among Flemish and Swiss, E/e? (6.78 vs. 6.73) and dp-ucMGP (3.94 ?g/L vs. 4.20 ?g/L) were similarly distributed. In multivariable-adjusted models, for each doubling of dp-ucMGP, E/e? increased by 0.26, 0.33 and 0.31 in Flemish, Swiss and both cohorts combined (P?0.026); the odds ratios for having E/e? ? 8.5 were 1.99, 3.29 and 2.36, respectively (P?0.017). Cardiac biopsies from patients with ischemic or dilated cardiomyopathy and healthy hearts (n = 4 for each) were stained with conformation-specific MGP antibodies. In diseased compared with normal hearts, uncarboxylated inactive MGP was more prevalent (P?0.004) in the perivascular matrix and interstitium (204.4 vs. 8.6 ?m2 per field) and phosphorylated active MGP in and around capillaries and interstitial cells (31.3 vs. 6.6 number of positive capillaries and cells per field). Conclusions: Our study supports a role of activated MGP in maintaining myocardial integrity and diastolic LV performance and can potentially be translated into new strategies for managing diastolic LV dysfunction and preventing its progression to heart failure. Twit Text FOAVip Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29529056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29529056 #FOAvip English Wikipedia <ref>{{Cite pmid|29529056}}</ref> Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction #MMPMID29529056 Wei FF; Trenson S; Monney P; Yang WY; Pruijm M; Zhang ZY; Bouatou Y; Huang QF; Ponte B; Martin PY; Thijs L; Kuznetsova T; Allegaert K; Janssens S; Vermeer C; Verhamme P; Burnier M; Bochud M; Ehret G; Staessen JA PLoS One 2018[]; 13 (3): ä PMID29529056show ga Objectives: A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure?a measure of diastolic LV dysfunction?increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium. Methods: We measured echocardiographic diastolic LV function and plasma dp-ucMGP (ELISA) in 668 Flemish and for replication in 386 Swiss. Results: Among Flemish and Swiss, E/e? (6.78 vs. 6.73) and dp-ucMGP (3.94 ?g/L vs. 4.20 ?g/L) were similarly distributed. In multivariable-adjusted models, for each doubling of dp-ucMGP, E/e? increased by 0.26, 0.33 and 0.31 in Flemish, Swiss and both cohorts combined (P?0.026); the odds ratios for having E/e? ? 8.5 were 1.99, 3.29 and 2.36, respectively (P?0.017). Cardiac biopsies from patients with ischemic or dilated cardiomyopathy and healthy hearts (n = 4 for each) were stained with conformation-specific MGP antibodies. In diseased compared with normal hearts, uncarboxylated inactive MGP was more prevalent (P?0.004) in the perivascular matrix and interstitium (204.4 vs. 8.6 ?m2 per field) and phosphorylated active MGP in and around capillaries and interstitial cells (31.3 vs. 6.6 number of positive capillaries and cells per field). Conclusions: Our study supports a role of activated MGP in maintaining myocardial integrity and diastolic LV performance and can potentially be translated into new strategies for managing diastolic LV dysfunction and preventing its progression to heart failure. äEpidemiological and histological findings implicate matrix Gla protein(epmc).pdf DeepDyve Pubget Overpricing