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10.1371/journal.pone.0193967 http://scihub22266oqcxt.onion/10.1371/journal.pone.0193967 C5846787!5846787 !29529056     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29529056 &cmd=llinks): Failed to open stream: HTTP request failed! 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Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction |pdf=|usr=}}{{29529056 }} gab.com Text Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29529056 #FOAvip OBJECTIVES: A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium. METHODS: We measured echocardiographic diastolic LV function and plasma dp-ucMGP (ELISA) in 668 Flemish and for replication in 386 Swiss. RESULTS: Among Flemish and Swiss, E/e' (6.78 vs. 6.73) and dp-ucMGP (3.94 ?g/L vs. 4.20 ?g/L) were similarly distributed. In multivariable-adjusted models, for each doubling of dp-ucMGP, E/e' increased by 0.26, 0.33 and 0.31 in Flemish, Swiss and both cohorts combined (P?0.026); the odds ratios for having E/e' ? 8.5 were 1.99, 3.29 and 2.36, respectively (P?0.017). Cardiac biopsies from patients with ischemic or dilated cardiomyopathy and healthy hearts (n = 4 for each) were stained with conformation-specific MGP antibodies. In diseased compared with normal hearts, uncarboxylated inactive MGP was more prevalent (P?0.004) in the perivascular matrix and interstitium (204.4 vs. 8.6 ?m2 per field) and phosphorylated active MGP in and around capillaries and interstitial cells (31.3 vs. 6.6 number of positive capillaries and cells per field). CONCLUSIONS: Our study supports a role of activated MGP in maintaining myocardial integrity and diastolic LV performance and can potentially be translated into new strategies for managing diastolic LV dysfunction and preventing its progression to heart failure. Twit Text FOAVip Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29529056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29529056 #FOAvip English Wikipedia <ref>{{Cite pmid|29529056 }}</ref> Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction #MMPMID29529056 Wei FF ; Trenson S ; Monney P ; Yang WY ; Pruijm M ; Zhang ZY ; Bouatou Y ; Huang QF ; Ponte B ; Martin PY ; Thijs L ; Kuznetsova T ; Allegaert K ; Janssens S ; Vermeer C ; Verhamme P ; Burnier M ; Bochud M ; Ehret G ; Staessen JA PLoS One 2018[]; 13 (3 ): e0193967 PMID29529056 show ga OBJECTIVES: A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium. METHODS: We measured echocardiographic diastolic LV function and plasma dp-ucMGP (ELISA) in 668 Flemish and for replication in 386 Swiss. RESULTS: Among Flemish and Swiss, E/e' (6.78 vs. 6.73) and dp-ucMGP (3.94 ?g/L vs. 4.20 ?g/L) were similarly distributed. In multivariable-adjusted models, for each doubling of dp-ucMGP, E/e' increased by 0.26, 0.33 and 0.31 in Flemish, Swiss and both cohorts combined (P?0.026); the odds ratios for having E/e' ? 8.5 were 1.99, 3.29 and 2.36, respectively (P?0.017). Cardiac biopsies from patients with ischemic or dilated cardiomyopathy and healthy hearts (n = 4 for each) were stained with conformation-specific MGP antibodies. In diseased compared with normal hearts, uncarboxylated inactive MGP was more prevalent (P?0.004) in the perivascular matrix and interstitium (204.4 vs. 8.6 ?m2 per field) and phosphorylated active MGP in and around capillaries and interstitial cells (31.3 vs. 6.6 number of positive capillaries and cells per field). CONCLUSIONS: Our study supports a role of activated MGP in maintaining myocardial integrity and diastolic LV performance and can potentially be translated into new strategies for managing diastolic LV dysfunction and preventing its progression to heart failure. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Calcium-Binding Proteins/*metabolism [MESH] |Cardiomyopathy, Dilated/diagnostic imaging/metabolism/pathology/surgery [MESH] |Cohort Studies [MESH] |Electrocardiography [MESH] |Extracellular Matrix Proteins/*metabolism [MESH] |Female [MESH] |Heart Transplantation [MESH] |Heart/diagnostic imaging [MESH] |Humans [MESH] |Male [MESH] |Matrix Gla Protein [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Myocardial Ischemia/diagnostic imaging/metabolism/pathology/surgery [MESH] |Myocardium/*metabolism/*pathology [MESH] |Netherlands [MESH] |Switzerland [MESH] |Ventricular Dysfunction, Left/diagnostic imaging/epidemiology/*metabolism/*pathology [MESH]Epidemiological and histological findings implicate matrix Gla protein(epmc).pdf DeepDyve Pubget Overpricing