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10.1371/journal.pone.0193288

http://scihub22266oqcxt.onion/10.1371/journal.pone.0193288
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C5846770!5846770!29529055
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suck abstract from ncbi


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pmid29529055      PLoS+One 2018 ; 13 (3): ä
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  • Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration #MMPMID29529055
  • Mas S; Bosch-Panadero E; Abaigar P; Camarero V; Mahillo I; Civantos E; Sanchez-Ospina D; Ruiz-Priego A; Egido J; Ortiz A; González-Parra E
  • PLoS One 2018[]; 13 (3): ä PMID29529055show ga
  • Introduction: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF. Methods: A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron). Results: After a run-in OL-HDF period of at least 6 months with the same membrane, baseline pre-dialysis BPA was lower in patients on polynephron (8.79±7.97 ng/ml) than in those on polysulfone (23.42±20.38 ng/mL, p<0.01), but still higher than in healthy controls (<2 ng/mL). After 3 months of polynephron-to-polysulfone switch, BPA was unchanged (8.98±7.88 to 11.14±15.98 ng/mL, ns) while it decreased on the polysulfone-to-polynephron group (23.42±20.38 to 11.41±12.38 ng/mL, p<0.01). Conclusion: OL-HDF for 3 months with BPA-free dialyzer membranes was associated to a significant decrease in predialysis BPA levels when compared to baseline BPA levels while on a BPA-containing membrane.
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